What Makes You Who You Are

Topics: Human genome, DNA, Gene Pages: 2 (547 words) Published: April 20, 2013
The perennial debate about nature and nurture--which is the more potent shaper of the human essence?--is perennially rekindled. It flared up again in the London Observer of Feb. 11, 2001. REVEALED: THE SECRET OF HUMAN BEHAVIOR, read the banner headline. ENVIRONMENT, NOT GENES, KEY TO OUR ACTS. The source of the story was Craig Venter, the self-made man of genes who had built a private company to read the full sequence of the human genome in competition with an international consortium funded by taxes and charities. That sequence--a string of 3 billion letters, composed in a four-letter alphabet, containing the complete recipe for building and running a human body--was to be published the very next day (the competition ended in an arranged tie). The first analysis of it had revealed that there were just 30,000 genes in it, not the 100,000 that many had been estimating until a few months before.

Details had already been circulated to journalists under embargo. But Venter, by speaking to a reporter at a biotechnology conference in France on Feb. 9, had effectively broken the embargo. Not for the first time in the increasingly bitter rivalry over the genome project, Venter's version of the story would hit the headlines before his rivals'. "We simply do not have enough genes for this idea of biological determinism to be right," Venter told the Observer. "The wonderful diversity of the human species is not hard-wired in our genetic code. Our environments are critical."

In truth, the number of human genes changed nothing. Venter's remarks concealed two whopping nonsequiturs: that fewer genes implied more environmental influences and that 30,000 genes were too few to explain human nature, whereas 100,000 would have been enough. As one scientist put it to me a few weeks later, just 33 genes, each coming in two varieties (on or off), would be enough to make every human being in the world unique. There are more than 10 billion combinations that could come from...
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