Ulcerative Colitis Disease

Topics: Ulcerative colitis, Crohn's disease, Colon Pages: 11 (3636 words) Published: October 25, 2012
What is the most affective medicine between balsalazide, 6.75 g Sulfasalazine 3.0g to treat ulcerative colitis? Introduction
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http://gastrointestinalatlas.com/UlcerativeColitisPc3.jpgUlcerative colitis is becoming a common condition in the UK . It is estimated that there are ten new cases a year out of every 100,000 people. There are currently 100,000 people in England with ulcerative colitis. The condition normally appears between the ages of 15 and 30[1]. This figure is supposed to rise in the coming years. Doctors are becoming more baffled as they do not know what is the right effective drug for their patient’s treatment. The two main drugs that are being used at the moment is balsalazide and Sulfasalazine. Both drugs are classed under a treatment called 5-ASA. For this type of treatment these are the two main drugs used by all doctors. [6]

Ulcerative colitis is grouped under a name of a disease called Inflammatory Bowel disease. Inflammation has a literal meaning of “being set on fire”. Inflammation normally occurs when a tissue has been damaged or destroyed; it is like the body’s response to tell you something is wrong [2]. In other words Ulcerative colitis in which the large intestine, but not the small, becomes inflamed and ulcerated. In Ulcerative colitis it is only the inner lining of the bowel, and not it’s full thickness, which is affected. Ulcerative colitis may affect the rectum, when it is usually called ‘proctitis’, or it may affect the bowel from anus to the top left of the colon (splenic flexure). [6]

Where does ulcerative colitis occur?
Ulcerative colitis occurs in the colon. It always involves the rectum. It should be continuous, but can also be confined to patches in the colon. Some patients just experience inflammation in the rectum, others have it in the rectum and the sigmoid colon. The patients who suffer badly from the disease, normally have inflammation throughout the colon. Graph 1


Who Gets Ulcerative colitis?

Ulcerative colitis can begin at any age. Most commonly it appears between the ages of 15-30 or-less often-between the ages of 45and 60. It occurs all around the world but it is much more common in the warmer tropical climates. The disease is normally detected in more developed countries for example the UK and North America.[3] As we can see from Graph 1, which is a graph from the patients in North America who suffer from ulcerative colitis. We can see that both males and females are equal in incidence with 50% each. This means we can tell that Ulcerative colitis can affect both sexes equally and this causes a bigger problem as we do not know what drug works better on males the females or both.

What causes Ulcerative Colitis ?
Doctors know a lot about ulcerative colitis but there is yet to be a cause to be found. Doctors believe that there are a number of factors that affect ulcerative colitis. Firstly genetics, it seems that the genes you inherit from your parents plays a big role of developing ulcerative colitis. Studies have shown that around 16% of people who have the disease have a close relative with the same condition. Scientist have found many genes that are able to code for ulcerative colitis, but how they do not know. Secondly the environmental factors around you have a big play on ulcerative colitis: Where and how we live also seems to play a role in the development of ulcerative colitis. The condition is much more common in certain parts of the world - namely, urban areas in northern parts of Western Europe and America. A number of environmental factors have been suggested, including. Diet - the typical Western diet is high in carbohydrates and fats, which may explain why Asian people, who tend to eat a diet lower in carbohydrates and fats, are less affected by ulcerative colitis Hygiene - children are being brought up in increasingly germ-free...
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