Tumor Lysis Syndrome

Topics: Metabolic acidosis, Nephrology, Uric acid Pages: 4 (604 words) Published: May 26, 2013
Tumor Lysis Syndrome
by NinjaMom

Tumor Lysis Syndrome is a series of metabolic derangements which may begin shortly after the onset of treatment of malignancies. It can lead to any of the following:

· hyperphosphatemia· lactic acidosis (metabolic acidosis)
· hypocalcemia· hyperuricemia
· hyperkalemia· acute renal failure

Tumor Lysis Syndrome (TLS):

· is caused by the destruction of many rapidly proliferating neoplastic cells
· is most commonly associated with a Burkitt's lymphoma or acute lymphocytic leukemia
· can occur after treatment of nearly any malignancy
· occurs shortly (1-5 days) after onset of chemotherapy
· can occur spontaneously, but this is rare

There are no definite parameters to diagnosing TLS, but there is a guideline as to how to measure disease severity. This is the Cairo-Bishop method.

Laboratory TLS - two or more of the following:

· uric acid level > 8· potassium level > 6
· phosphorus level > 4.5· calcium level < 7

Clinical TLS - any of the above laboratory values with an elevated serum creatinine, a new arrhythmia, seizure or sudden death


· caused by the release of intracellular phosphate pools within tumor cells
· causes a reciprocal decrease in serum calcium, which then
· causes the deposition of calcium phosphate crystals in the renal tubules and in the microvasculature, and can lead to acute renal failure
· treat with oral phosphate binders


· usually a reciprocal decrease caused by hyperphosphatemia
· QT prolongation
· positive Chvostek and Trousseau's signs
· bronchospasm, seizures, anxiety, tetany, encephalopathy, unexplained dementia or psychosis, parasthesias
· often resolves without intervention as the phosphate levels return to normal
· do NOT correct unless severe neurological symptoms present as this may predispose the patient to hypercalcemia as the phosphate levels normalize...
Continue Reading

Please join StudyMode to read the full document

You May Also Find These Documents Helpful

  • Essay on Xyy Syndrome, Jacob Syndrome
  • Famous tumors Essay
  • Jacobs Syndrome Essay
  • Savant Syndrome Essay
  • Stockholm Syndrome Essay
  • Down Syndrome Essay
  • Klinefelter Syndrome Essay
  • Rett's Syndrome Essay

Become a StudyMode Member

Sign Up - It's Free