Toxoplasma Gondi Infection in Mice

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  • Topic: Immune system, Rat, Toxoplasma gondii
  • Pages : 3 (873 words )
  • Download(s) : 83
  • Published : May 12, 2013
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GI (Gastro-Intestinal) inflammation from Toxoplasma gondii and wheat glutens contribute to schizophrenia, autism and bipolar disorder. It has been suggested that GI inflammation, allows natural microbiota and neuroactive exorphins to enter the blood steam, cross the blood brain barrier and attach to the opioid receptors. In this study exposure to Toxoplasma gondii increased anti-gluten IgG in all the mice who were inoculated. The mice were infected in three different ways, IP (injection into the peritoneal cavity), PO (fed food inoculated with the pathogen) and prenatally (injected).When the female mice were Infected IP, they were more likely to die than males. The mock group of females injected IP, had an increased gluten IgGs, while the males did not. The female immune system responded to stress. When both male and female mice received the pathogen PO, females displayed a larger anti-gluten response. When the females were injected prenatally, the offspring produced, were seropositive to T. gondii and displayed increased gluten IgG levels. Clq levels of the offspring were also elevated (Clq plays a role in synaptic pruning).

I picked an article from PLOS (Public Library of Science),created by Dr. Patrick Brown, a biochemist at Stanford University and Dr. Michael Eisen, a computational biologist at UC Berkeley and Lawrence Berkeley National Laboratory. They wanted to speed up progress in science and medicine by creating a nonprofit-open access, to scientific journals and literature under an open content license called the Creative Commons “attribution” license. This allowed any person to reproduce and distribute information from the website. This allows all people to learn/share knowledge, repeat tests and add more information to current studies. This site is peer reviewed and respected as a reliable source of information.

My article has many authors and sources, but in order to keep my critique to two pages I picked the first three people on the works...
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