The Anthelmintic Property of Methanolic and Ethanolic Extract of the Kulitis Leaves

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  • Topic: Tannin, Glycoside, Parasitic worm
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  • Published : May 5, 2013
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The Anthelmintic Property of Methanolic and Ethanolic extract of the Kulitis leaves

(Amaranthus viridis)

Chapter 1

Introduction

The World Health Organization estimates that a staggering two billion people harbor parasitic worm infections. Parasitic worm also infect livestock and

crops, affecting food production with a resultant economic impact. Despite this

pevelance of parasitic infections, the research o the Anthelmintic drug is sparse.

According to the WHO, only a few drugs are used in the treatment of helminthes,

treatment of these parasite infections. In view of this, attempts have been made

to studt the anthelmintic activity of traditional medicinal plants. For our studies,

we used Kulitis (Amaranthus viridis) that belong to the Amaranthaceae family

and are traditionally used as vermifuge drugs (Fajimi anf\d 2007), anti-malarial

activity (Hilou et al., 2006), antiadronergic activity (Murgan et al., 1993), effects

on biochemical changes in the epididymis (Murgan et al., 1993), anti-diabetic,

anti-hyperlipidemic and spermatogenic activity (Sangameswaran and Jayakar,

2008).

The prevention of disease particularly in diminishing intestinal parasites is

a major problem especially in developing countries where there is a need for

adequate health care and facilities. The use of  these plant Kulitis (Amaranthus

viridis) could play a key role for treating people harboring parasitic worm

infections.

Plants are particularly interesting source of important substances. Plants

products have been used in the treatment of diseases for many years and could

be considered to be the first drugs.

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The medicinal virtues of the plant Kulitis (Amaranthus viridis) are not well

known to Filipinos. Most scientist have begun to prove the scientific basis for

the use of these plants in medicine.

The investigation lead to determine the possible constituent present in

Kulitis (Amaranthus viridis) and to determine the wormicidal activity of the methanolic

and ethanolic extract of the Kulitis (Amaranthus viridis) leaves.

.

Conceptual Framework

To perform different processes on the Kulitis (Amaranthus viridis) leaf for the determination of the constituent . Preliminary investigation were conducted to prove the active constituents present in Kulitis (Amaranthus viridis) such as saponin glycoside, cardenolides and bufadienolides, tannins, flavonoids, anthraquinone. The Leaves contains anthraquinone derivatives, cardiac glycosides and saponins. Study yields 18 kinds of amino acids, 8 of which are essential.Contains 7-p-coumaroyl apigenin 4-O-beta-D-glucopyranoside, a new coumaroyl flavone glycoside called spinoside, xylofuranoxyl uracil, beta-D-ribofuranosyl adenine, beta-sitosterol glucoside, hydroxycinnamates, quercetin and kaempferol glycosides, betalains, betaxanthin, betacyanin; amaranthine and isoamaranthine, gomphrenin, betanin, b-sitosterol, stigmasterol, linoleic acid, rutin and beta- carotene. (http://www.stuartxchange.org/Uray.html)

The Research Paradigm

Input Process Output

1. Maceration

2. Phytochemical screening

3. Quantitative analysis

a. Moisture content

b. ash determination

• Efficacy Test

Anthel-mintic

Kulitis (Amaranthus viridis) plant extract

Figure 1

Paradigm of the Study

The leaf extract of Amaranthus viridis is prepared by macerating in 80% ethyl alcohol. Then Phytochemical screening was done to determine the presence of alkaloids, saponin glycosides, tannins, fats and oils,...
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