Tetralogy of Fallot

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Developmental 561

DUE: March 31st, 2011 Questions for DEV BIOL 561: These questions will serve as your attendance for today and as your March problem set. Use your notes and books to answer the questions below. You are not to work in groups!

1. Explain the Tetralogy of Fallot and its major defects. Also explain how each defect may cause abnormal heart functions.

A congenital malformation of the heart characterized by a defect in the ventricular septum, misplacement of the origin of the aorta, narrowing of the pulmonary artery, and enlargement of the right ventricle.

2. A child is born with severe craniofacial defects and transposition of the great vessels. What cell population may play a role in both abnormalities, and what type of insult might have produced this effect?

3. A prenatal ultrasound of a 35-year-old woman in her 12th week of gestation reveals an abnormal image of the fetal heart. Instead of a four-chambered view provided by the typical cross, a portion just below the crosspiece is missing. What structures constitute the cross, and what defect does this infant probably have?

4. What portion of the heart is derived from the bulbis cordis?

5. Later in her pregnancy, a woman realizes that she was probably exposed to thalidomide in the workplace during the third week of gestation but tells a fellow worker that she is not concerned about her baby because the placenta protects her infant from toxic factors by acting as a barrier. Is she correct? What potential birth defect(s) may her unborn child develop? Is exposure to this chemical at the 3rd week create more concern than if the exposure would have occurred at the 30th week?
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