Teaching Plan

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TEACHING PLAN: 11NT310 – 12CH316 ADVANCED PHARMACEUTICAL CHEMISTRY Credits 4:0:0
November2012 to April 2012

Name of the Faculty member: Mr. G. Yowan Nerthigan Designation: Assistant Professor Specialization – MSc Chemistry(II year)Dept / School: Science and Humanities / School of Nanoscience and Technology Unit

No.
Lecture
No.
Topic
Book & Page Nos.
Used for teaching
Topic No.
Date Taught
Unit 1
BASICS OF MEDICINAL CHEMISTRY
1,2
Introduction to drug design
Medicinal Chemistry by Ashutosh Kar
1

3
Physical and
chemical factors associated with biological activities
Medicinal Chemistry by Ashutosh Kar
2

4,5
Classification of drugs based on structure
or pharmacological basis with examples
Medicinal Chemistry by Ashutosh Kar
3

6,7
Pro drugs and soft drugs

4

8,9
Design of pro drug system
– Multiple pro drug formation
Medicinal Chemistry by Ashutosh Kar
5

10, 11
Soft drug principle and applications
Journal Article
6

12
Quantitative Structure
Activity Relationship –
Medicinal Chemistry by Ashutosh Kar & Medicinal Chemistry by Gareth Thomas 7

13, 14
Chirality in Drug Design.
Journal Article
8

Unit II
DRUG DISCOVERY AT THE ENZYME LEVEL
15
Unit II
DRUG DISCOVERY AT THE ENZYME LEVEL

16
Enzymes and enzyme inhibitors
Medicinal Chemistry by Gareth Thomas
9

17
Competitive and non-competitive inhibitors
Medicinal Chemistry by Gareth Thomas
10

18, 19
Reversible and irreversible inhibitor
Medicinal Chemistry by Gareth Thomas
11

20, 21
Ligand receptor theories
Medicinal Chemistry by Gareth Thomas
12

22, 23
Clark’s theory and Paton’s rate theory
Medicinal Chemistry by Gareth Thomas
13

24, 25
Proteins, lipids, and nucleic acids as
drug targets
Medicinal Chemistry by Gareth Thomas
14

26, 27
Effect of pH, pKa, and polarity on drug solubility
Medicinal Chemistry by Gareth Thomas
15

28
DNA Protein interaction and
DNA drug interaction
Medicinal Chemistry by Ashutosh Kar & Medicinal Chemistry by Gareth Thomas 16

Unit III
DRUG ACTION AND DRUG METABOLISM
29
Drug action – Ideal requirement of a drug
Medicinal Chemistry by Ashutosh Kar & Medicinal Chemistry by Gareth Thomas 17

30
sources of drug plant and animal origin
Medicinal Chemistry by Ashutosh Kar & Medicinal Chemistry by Gareth Thomas 18

31
Mechanism of Drug
Action
Medicinal Chemistry by Ashutosh Kar & Medicinal Chemistry by Gareth Thomas 19

32,33
Absorption, distribution, metabolism, and elimination
Medicinal Chemistry by Ashutosh Kar & Medicinal Chemistry by Gareth Thomas 20

34
Oxidation and hydrolysis
Medicinal Chemistry by Ashutosh Kar & Medicinal Chemistry by Gareth Thomas 21

35
Testing drugs in vitro
Medicinal Chemistry by Ashutosh Kar & Medicinal Chemistry by Gareth Thomas 22

36
High-throughput screening
Medicinal Chemistry by Ashutosh Kar & Medicinal Chemistry by Gareth Thomas 23

37
Testing drugs in vivo
Medicinal Chemistry by Ashutosh Kar & Medicinal Chemistry by Gareth Thomas 24

38
Therapeutic index
and therapeutic ratio
Medicinal Chemistry by Ashutosh Kar & Medicinal Chemistry by Gareth Thomas 25

Unit IV
DEVELOPMENT OF NEW DRUGS & TYPES OF DRUGS:
39
Five classic steps in the design
of a new drug
Medicinal Chemistry by Ashutosh Kar & Medicinal Chemistry by Gareth Thomas 26

40, 41
Procedures in drug design
Medicinal Chemistry by Ashutosh Kar
27

42, 43
Molecular modification of lead compounds
Medicinal Chemistry by Ashutosh Kar
28

44, 45
Factors affecting drug development
Medicinal Chemistry by Ashutosh Kar
29

46
Analgesics – Local and General Analgesics

30

47, 48
Classification
– Mechanism of action with examples
Medicinal Chemistry by Ashutosh Kar
31

49
Anesthetics – Local and General Analgesics
Medicinal Chemistry by...
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