Tablet Manufacturing Area

Only available on StudyMode
  • Download(s) : 98
  • Published : July 12, 2011
Open Document
Text Preview
TABLET MANUFACTURING AREA:
TABLET: A tablet is a pharmaceutical dosage form. It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from a powder into a solid dose. The excipients can include diluents, binders or granulating agents, glidants (flow aids) and lubricants to ensure efficient tabletting; disintegrants to promote tablet break-up in the digestive tract; sweeteners or flavours to enhance taste; and pigments to make the tablets visually attractive. A polymer coating is often applied to make the tablet smoother and easier to swallow, to control the release rate of the active ingredient, to make it more resistant to the environment (extending its shelf life), or to enhance the tablet's appearance. TABLET MANUFACTURING PROCESS:

1. Batch Manufacturing Record
Any production in the pharmaceutical industry is followed strictly and blindly according to previously developed protocols. So for production, the entire process, precautions, equipment, conditions to be maintained are mentioned in the Batch Manufacturing Record (BMR). This BMR is documented by the R&D unit and checked for improvements by the Analytical Development unit. 2. Dispensing Of Raw Material

Dispensing is the first step in any pharmaceutical manufacturing process. Dispensing is one of the most critical step in pharmaceutical manufacturing; as during this step, the weight of each ingredient in the mixture is determined according to dose. Dispensing may be done by purely manual by hand scooping from primary containers and weighing each ingredient by hand on a weigh scale, manual weighing with material lifting assistance like Vacuum transfer and Bag lifters, manual or assisted transfer with automated weighing on weigh table, manual or assisted filling of loss-in weight dispensing system, automated dispensaries with mechanical devices such as vacuum loading system and screw feed system. Issues like weighing accuracy, dust control (laminar air flow booths, glove boxes), during manual handling, lot control of each ingredient, material movement into and out of dispensary should be considered during dispensing. 3. GRANULATION PROCESS(TWO GRANULATION ROOMS)

WET GRANULATION| DRY GRANULATION| DIRECT COMPRESSION|
1.
Milling
and mixing of drugs and excipients| 1.
Milling
and mixing of drugs and excipients| 1. Milling and mixing of drugs and excipients| 2.
Preparation
of binder solution| 2.
Compression
into slugs or roll compaction| 2.
Compression of tablet|
3.
Wet
massing by addition of binder solution
or granulating solvent| 3.
Milling
and screening of slugs and compacted powder|  |
4.
Screening
of wet mass| 4.
Mixing
with lubricant and disintegrant|  |
5.
Drying
of the wet granules| 5.
Compression
of tablet|  |
6.
Screening
of dry granules|  |  |
7.
Blending
with lubricant and disintegrant to produce “running powder”|  |  | 8.
Compression
of tablet|  |  |
| | | |

FLOW CHART OF TABLET MANUFACTURING PROCESS:

DIRECT COMPRESSION:

FLOW CHART OF TABLET MANUFACTURING PROCESS:

WET GRANULATION:

FLOW CHART OF TABLET MANUFACTURING PROCESS:

DRY GRANULATION:

FLOW CHART OF TABLET MANUFACTURING PROCESS:

WET GRANULATION:

4. COMPRESSION PROCESS(FOUR COMPRESSION ROOMS)
After the preparation of granules (in case of wet granulation) or sized slugs (in case of dry granulation) or mixing of ingredients (in case of direct compression), they are compressed to get final product. The compression is done either by single punch machine (stamping press) or by multi station machine (rotary press).The tablet press is a high-speed mechanical device. It 'squeezes' the ingredients into the required tablet shape with extreme precision. It can make the tablet in many shapes, although they are usually round or oval. Also, it can press the name of the manufacturer or the product into the...
tracking img