Synthesis of Aspirin

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Lab Report
Synthesis and Characterization of Aspirin
(Acetylsalicylic Acid)

The Synthesis and Characterization of Aspirin (Acetylsalicylic Acid).

In this experiment, we produced 4.21 g of acetylsalicylic acid. Our theoretical yield was calculated to be 5.22 g. Therefore our % yield was determined to be 80.6%. The experimental boiling point range of acetylsalicylic acid was found to be 130-132° C. The true melting point of acetylsalicylic acid is 135° C, therefore our percent error range of for the boiling point is found to be 2.2 - 3.7 %. Introduction:

Aspirin or acetylsalicylic acid (ASA) is a salicylate drug often used as an analgesic to relieve minor aches and pains, antipyretic to reduce fever, and as an anti-inflammatory. It is also used as an anti-platelet agent. It works by preventing the synthesis of prostaglandins by inhibiting both the cyclooxygenase–1 (COX–1), which mediates platelet aggregation, gastric protection, and induction of renal function and cyclooxygenase–2 (COX–2) isoenzymes, which mediates tissue inflammation. Aspirin is in a class of medications called salicylates. Common adverse effects include: gastrointestinal (GI) distress (including upset stomach, heartburn, nausea, vomiting). Less common severe adverse effects include: tinnitus, Reye syndrome, GI ulceration, allergic reactions (including hives, shortness of breath, swelling, and/or anaphylaxis.) Aspirin should not be taken with other salicylates, non–steroidal anti–inflammatory drugs (NSAIDs) such as ibuprofen or naproxen sodium, or anticoagulants such as Coumadin (warfarin). Aspirin can be purchased both over–the–counter (OTC) and by prescription (Rx) from a physician. OTC preparations: Aspergum, Bayer Aspirin, Bufferin, Ecotrin, Empirin, Halfprin, St. Joseph Aspirin, and many generics. Rx preparation: ZORprin Aspirin is synthesized from the acetylation (using acetic anhydride or acetyl chloride) of salicylic acid. Salicylic acid is a natural product that...
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