Synthesis of Aspirin

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Synthesis of Aspirin

An Investigatory Project
Presented to:
Edmundo A. Quiñones
Chemistry Teacher

In Partial Fulfillment of the Requirements
Science and Technology III (Chemistry)

Presented by:
Kenneth Ivan P. Durano
Cyrill Val G. Lozano

March 6, 2010


This investigatory project entitled “The Synthesis of Aspirin” requirement for Science and Technology III (Chemistry) has been examined and is recommended for acceptance and approved for oral defense.

Edmundo A. Quiñones Chemistry Teacher

Accepted and approved in partial fulfillment of the requirements for Science and Technology III (Chemistry) with the grade of _______%.

Edmundo A. Quiñones Chemistry Teacher

Dedication to
The researchers’
Loving and Supportive Parents, Friends,
Teachers and Classmates,
This precious piece of work is humbly dedicated


The researchers would like to express their wholehearted gratitude to all who have contributed for the completion of this research study. We are greatly indebted to the following individuals: To Mr. and Mrs. Hermogenes Lozano and Mr. and Mrs. Lexdeo Durano for their unfailing support exerted in this study especially for the moral and financial support, To Mrs. Lucivel Fausto, the librarian, who willingly permitted some materials to be borrowed needed for the review of related literature and studies, To the classmates and friends of the researchers who willingly helped and exerted effort for the completion of this study, And especially, to the Almighty and ever Loving God, who gave unconditional support and strength to make this investigatory project a success.


The study is mainly concerned on synthesis of aspirin, acetylsalicylic acid, which is most widely used as a nonprescription drug and is used to treat mild to moderate pain, and also to reduce fever or inflammation. Synthesis of aspirin refers to a process of salicylic acid reacting with glacial acetic acid. The product then is purified by repeated process called crystallization. In this experiment, the researchers combined the salicylic acid, glacial acetic acid and phosphoric acid in a flask and dissolved the mixture in a hot bath. After the mixture completely dissolved, the solution was added with distilled water and is placed in an ice bath to speed up the crystallization process. After the crystallization is complete, the crystals are filtered to remove the excess water. To further purify the product, crystallization has been repeated by adding a solution of ethanol and distilled water to the residue. After two successive recrystallizations, the residue is then air-dried and weighed. After three successive trials, the researchers had obtained 1.76g, 2.69g and 1.18g of aspirin for the first, second, and third trials respectively. For the first trial, the researchers had obtained 50% yield, 69% yield for the second trial, and 60% for the third trial. In addition, the researchers, to those who want to make this kind of project for the future, recommend to make sure that during experiment, the researchers should avoid shifting containers to avoid the subtraction of the mass of the product.

The Problem and Its Scope

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