Sudden Infant Death Cyndrome

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Sudden infant death syndrome
Rachel Y Moon, Rosemary S C Horne, Fern R Hauck
Lancet 2007; 370: 1578–87 Goldberg Center for Community Pediatric Health, Children’s National Medical Center and George Washington University School of Medicine and Health Sciences, Washington, DC, USA (R Y Moon MD); Ritchie Centre for Baby Health Research, Monash Institute for Medical Research, Monash University, Melbourne, Australia (R S C Horne PhD); and Departments of Family Medicine and Public Health Sciences, University of Virginia School of Medicine Charlottesville, Virginia, USA (F R Hauck MD) Correspondence to: Rachel Y Moon, Children’s National Medical Center, Michigan Avenue NW, Washington, DC 20010, USA

Despite declines in prevalence during the past two decades, sudden infant death syndrome (SIDS) continues to be the leading cause of death for infants aged between 1 month and 1 year in developed countries. Behavioural risk factors identified in epidemiological studies include prone and side positions for infant sleep, smoke exposure, soft bedding and sleep surfaces, and overheating. Evidence also suggests that pacifier use at sleep time and room sharing without bed sharing are associated with decreased risk of SIDS. Although the cause of SIDS is unknown, immature cardiorespiratory autonomic control and failure of arousal responsiveness from sleep are important factors. Gene polymorphisms relating to serotonin transport and autonomic nervous system development might make affected infants more vulnerable to SIDS. Campaigns for risk reduction have helped to reduce SIDS incidence by 50–90%. However, to reduce the incidence even further, greater strides must be made in reducing prenatal smoke exposure and implementing other recommended infant care practices. Continued research is needed to identify the pathophysiological basis of SIDS.

Sudden infant death syndrome, or SIDS, is defined as “the sudden death of an infant under one year of...
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