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International Journal of Pharma and Bio Sciences
RESEARCH ARTICLE ARTICALTICLE MEDICINAL CHEMISTRY

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF SCHIFF BASES METAL COMPLEXES CO (II), ZN (II), NI (II), AND MN (II) DERIVED FROM AMOXICILLIN TRIHYDRATE WITH VARIOUS ALDEHYDES.

Corresponding Author

SUNIL JOSHI
Synthetic Lab, P. G. Department of Chemistry, Faculty of Science, Government College, Ajmer, Rajasthan (INDIA).

Co Authors

VATSALA PAWAR , AND V.UMA
Synthetic Lab, P. G. Department of Chemistry, Faculty of Science, Government College, Ajmer, Rajasthan (INDIA).

ABSTRACT
In the present investigation some new Schiff bases derived from Amoxicillin trihydrate with Cinnamaldehyde and p-Chlorobenzaldehyde and their complexes with bivalent transition metal ions viz. Co(II), Zn(II), Ni(II), and Mn(II), have been synthesized. The ligand and their metal complexes were characterized on the basis of elemental analysis and micro analytical datas. Shift in the characteristic spectral frequency of the metal complexes, confirms the coordination through metal ion with azomethine group. They were screened for antibacterial activity against several bacterial strains namely E. coli(-), S. aureus(+) M. luteus(+) and B. lichenformis(+) (ATCC), the metal complexes showed enhanced antibacterial activity compared to uncomplexed ligand.

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KEY WORD
Antibacterial activity, Amoxicillin trihydrate.

INTRODUCTION
Compound containing imines bases have not only found extensive application in organic synthesis,1-2 but several of these molecules display significant biological activity. In the last decade Schiff base ligands 3-6 have received more attention mainly because of their wide application in the field of catalysis and due to their antimicrobia, 11-12 anti-tuberculosis7 and anti-tumor activity. They easily form stable complexes with most transition metal ion.13-14 The development of the field of bioinorganic chemistry has increased the interest in Schiff base complexes, since it has been recognized that many of these complexes may serve as models for biologically important species.8 Coordination compound have been reported to act as enzyme inhibitor9 and are useful due to their pharmacological application.10 In view of the importance of such imines, we describe here the synthesis and characterization of Co(II), Zn(II), Ni(II) and Mn(II) complexes of cinnemaldehyde and p-chlorobenzaldehyde with amoxicillin trihydrate. IR spectra were recorded using KBR disc on a FT-IR spectrophotometer, Shimadzu 8201PC in the range of 4000-400cm-1. 1HNMR spectra were recorded in MeOD at room temperature. Elemental analysis was carried out on Elementar Vario ELIII . Conductance measurement of 10-3 M solution of the complexes in DMF was carried out on an Equiptronic model no. Eq-660A. Melting point of the ligands and their metal complexes were determined by open capillary method using sunsim electric melting point apparatus and are uncorrected. Molecular weight of ligands and their metal complexes were determined by Rast camphor method. Synthesis of the organic ligand (CmA, PbA) The aldehyde cinnamaldehyde (1 mol, 1.321gm), p-chlorobenzaldehyde (1 mol, 1.521gm.) were dissolved in methanol (10 ml) and added to the amoxicillin trihydrate (1 mol, 4.194 gm) dissolved in methanol (10 ml). To this KOH (0.1 % in methanol) was added to adjust the pH of the solution between 7-8 and then the mixture respectively was refluxed for 4 hrs. After complete refluxation Schiff base was separated out on removal of the solvent at room temp. A light yellowish and brown colored crystalline solid obtained and then dried over anhydrous CaCl2 in vacuum.

MATERIAL AND METHOD
All chemicals and solvent used were of analytical grade. All metal (II) salts were used as chloride.UV-VIS spectra were obtained on digital spectrophotometer in the range 300-900nm in DMF.

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