Foreword by Giovanni De Micheli
Editor Sandro Carrara EPFL Lausanne Switzerland sandro.cararra@epﬂ.ch
ISBN 978-1-4419-6168-6 e-ISBN 978-1-4419-6169-3 DOI 10.1007/978-1-4419-6169-3 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010938597 # Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identiﬁed as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer ScienceþBusiness Media (www.springer.com)
Much of our economy and way of living will be affected by nanotechnologies in the decade to come and beyond. Mastering materials at the molecular level and their interaction with living matter opens up unforeseeable horizons. Still much of the potentials of nano-biotechnology is untapped. Although we understand most basic principles of molecular interaction, the transformation of scientiﬁc results into robust technologies that can support health care and environment protection has still to take place. In other words, we are at the verge of a technological revolution that will bring to us a multitude of bio-electronic devices that interact with biological systems through intelligent – and possibly distributed – means of computation. The recent strong interest about cyber-physical systems is motivated by this trend. This book reviews the principles and practice of nano-bio-sensing. It covers extensively the basic principles of interaction of living matters with detectors and the transduction principles. It reviews surface science as well as electrical and optical technologies for bio-sensing. Nano-scale effects, inducing quantum conﬁnement, are speciﬁcally addressed along with their beneﬁts, such as the ampliﬁcation of sensing phenomena, yielding devices with higher sensitivity. Speciﬁc importance is given to low-power sensing techniques, as well as nonconventional means for powering the sensors, which may be very useful for implanted biosensors. Moreover, fault-tolerant bio-sensing systems are described. Overall, various physical, chemical, and electrical effects contribute jointly to enable the construction of a new generation of nano-bio-sensors. The importance of this research ﬁeld should not be underestimated. The healthcare sector will soon be able to beneﬁt from real-time sensors – in the body and on the body – that can predict speciﬁc pathologies and give the opportunity of preventive treatment. Pharmacology will be positively affected by means of creating rational and personalized drugs that can be tuned to the characteristics of the patient. Nutrition science and practice will beneﬁt from advances in sensors to enable the monitoring of the consumption of nutrients in the right combination and
quantity for the expected effort. Positive impact of these methods can be measured, for example, in the training of sportsmen and in managing the attention span of youths. A combination of electro-sensing technologies can rationalize work and living spaces, enabling better working and living conditions and speciﬁcally longer autonomy to the elderly. Similarly, these technologies can be used to monitor the environment, to protect us from infections and pollution, and raise the level of...