ANNUAL REVIEWS
Further
Click here for quick links to Annual Reviews content online, including:
Annu. Rev. Pathol. Mech. Dis. 2010.5:253-295. Downloaded from www.annualreviews.org by Portland State University on 02/06/12. For personal use only.
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Mammalian Sirtuins: Biological Insights and Disease Relevance
Marcia C. Haigis and David A. Sinclair
Glenn Laboratories for the Molecular Biology of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115; email: Marcia Haigis@hms.harvard.edu, David Sinclair@hms.harvard.edu
Annu. Rev. Pathol. Mech. Dis. 2010. 5:253–95 First published online as a Review in Advance on November 3, 2009 The Annual Review of Pathology: Mechanisms of Disease is online at pathmechdis.annualreviews.org This article’s doi: 10.1146/annurev.pathol.4.110807.092250 Copyright c 2010 by Annual Reviews. All rights reserved 1553-4006/10/0228-0253$20.00
Key Words
chromatin, metabolism, deacetylase, cancer, cardiovascular, inflammation
Abstract
Aging is accompanied by a decline in the healthy function of multiple organ systems, leading to increased incidence and mortality from diseases such as type II diabetes mellitus, neurodegenerative diseases, cancer, and cardiovascular disease. Historically, researchers have focused on investigating individual pathways in isolated organs as a strategy to identify the root cause of a disease, with hopes of designing better drugs. Studies of aging in yeast led to the discovery of a family of conserved enzymes known as the sirtuins, which affect multiple pathways that increase the life span and the overall health of organisms. Since the discovery of the first known mammalian sirtuin, SIRT1, 10 years ago, there have been major advances in our understanding of the enzymology of sirtuins, their regulation, and their ability to broadly improve mammalian physiology and... [continues]
Further
Click here for quick links to Annual Reviews content online, including:
Annu. Rev. Pathol. Mech. Dis. 2010.5:253-295. Downloaded from www.annualreviews.org by Portland State University on 02/06/12. For personal use only.
• Other articles in this volume • Top cited articles • Top downloaded articles • Our comprehensive search
Mammalian Sirtuins: Biological Insights and Disease Relevance
Marcia C. Haigis and David A. Sinclair
Glenn Laboratories for the Molecular Biology of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115; email: Marcia Haigis@hms.harvard.edu, David Sinclair@hms.harvard.edu
Annu. Rev. Pathol. Mech. Dis. 2010. 5:253–95 First published online as a Review in Advance on November 3, 2009 The Annual Review of Pathology: Mechanisms of Disease is online at pathmechdis.annualreviews.org This article’s doi: 10.1146/annurev.pathol.4.110807.092250 Copyright c 2010 by Annual Reviews. All rights reserved 1553-4006/10/0228-0253$20.00
Key Words
chromatin, metabolism, deacetylase, cancer, cardiovascular, inflammation
Abstract
Aging is accompanied by a decline in the healthy function of multiple organ systems, leading to increased incidence and mortality from diseases such as type II diabetes mellitus, neurodegenerative diseases, cancer, and cardiovascular disease. Historically, researchers have focused on investigating individual pathways in isolated organs as a strategy to identify the root cause of a disease, with hopes of designing better drugs. Studies of aging in yeast led to the discovery of a family of conserved enzymes known as the sirtuins, which affect multiple pathways that increase the life span and the overall health of organisms. Since the discovery of the first known mammalian sirtuin, SIRT1, 10 years ago, there have been major advances in our understanding of the enzymology of sirtuins, their regulation, and their ability to broadly improve mammalian physiology and... [continues]
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