Sickle Cell Anemia

Topics: Red blood cell, Sickle-cell disease, Bone marrow Pages: 3 (1001 words) Published: April 26, 2013
Sickle Cell Disease:
Journal Article Review

Kelsey Bowman
Bio 204: Anatomy and Physiology 2

Sickle cell disease is an autosomal recessive genetic disorder most common in African Americans, which results from a mutation affecting the amino acid sequence of the beta chains of hemoglobin molecules in red blood cells. The abnormal hemoglobin which causes the red blood cells to sickle is called hemoglobin S. Sickling occurs when the red blood cells are deoxygenated causing the cell to have a hard curved crescent shape. Due to their shape the sickle cells can become trapped in blood vessel walls causing a circulatory blockage and could cause tissues to become oxygen deprived, pain, infection, and organ damage. Red blood cells in sickle cell disease also have a life span of 10 to 20 days compared to normal red blood cells of 120 days; because of this shortened life span chronic hemolytic anemia occurs (Thompson, 2012). All together sickle cells disease causes a dramatic decrease in the quality of life that can lead to early death, the absolute need for medical intervention, and transplantations.

Almost all patient care is based upon treating and managing the symptoms that accompany sickle cell disease. Sickle cell disease severity varies from patient to patient making it hard to predict which patients will respond adequately to certain treatments. Individuals with severe complications from the disease itself would benefit best from aggressive treatments such as transplantations. Severe complications include pain, splenic crisis, acute chest syndrome, pulmonary hypertension, and stroke.

The articles by Thompson and Meier share the same information about sickle cell disease, the complications and risk of procedures, and what type of treatments are available. Although, the article by Thompson goes farther in depth on the cure of stem cell research and transplants versus the article by Meier with the main focus of symptoms and symptom...
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