Research Paper

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Research 1: “Efficacy and safety of hyaluronic acid in treatment of leg ulcers: a double-blind RCT”

Research 2: “The experience of patients with complex wounds and the use of NPWT in a home-care setting”

Introduction

The analysis that follows is about 2 studies that are related to medicine and are conducted in the field of health and social care which involve different methods to test experiences of patients who face problems like leg ulcers, and the treatment of patients with NPWT (Negative-pressure wound therapy) usage in a home setting. The first research the title of which is “Efficacy and safety of hyaluronic acid in treatment of leg ulcers: a double-blind RCT” pertains to a quantitative research analysis done with 101 patients and its main aim was to test the impact and usefulness as well as safety of using hyaluronic acid for treating leg ulcers of venous/mixed aetiology, as opposed to a neutral vehicle. The second article with the title “The experience of patients with complex wounds and the use of NPWT in a home-care setting” pertains to finding out experiences of patients who are suffering from complex wounds which are then treated by using NPWT for treating them. The paper that follows discusses the methodology, results, analysis and conclusion of both the studies.

Methodology

The research which was conducted regarding the treatment of leg ulcers using hyaluronic acid was a quantitative study and the methodology used for this research was to select patients from in and out patients list who were eligible for the test if they were over 18 years of age and had at least one leg ulcer of venous/mixed aetiology that prevailed between a period of 2 months-4 years. Some statistics were also specified for the kind of wound to be tested which means that the test was conducted under as fair/similar conditions of the patients as possible, for greater accuracy. Some exclusion criteria had also been identified for ensuring precision in the process. For each patient involved in the study, the wound (the target ulcer) had been appointed for being treated with a certain percentage of hyaluronic acid formulation for a certain time period (maximum of 60 days or till the wound heals). Some were assigned for the control treatment as well for the purpose of comparison of the two treatments. The end point was ultimately the reduction in wound size at day 45 and minor aims were to test pain reduction as well as the rate at which the wound had been healing. Once again, to guarantee the uniformity in procedure, both treatments were given in the same form, under same conditions for maintenance of double blinding. Even the randomization process was based on a computer generated list with appropriate data management using validated software so that a standard for procedures was maintained. To cut it short, it was a 60-daydouble blind test, which was randomized and conducted in a highly controlled environment with 101 patients for a period of 2 years (2007-2009)

For the second research which was based on qualitative data, was supposed to test whether the experiences of patients who had been living with complex wounds under the impact of NPWT (Negative Pressure Wound Therapy) as part of their treatment improves or stays the same. For the purpose of conducting this study in particular, qualitative data was collected from a total of 8 patients who were interviewed using a questionnaire that had semi-structures questions to gauge facts as well as feelings from patients because such a study requires more of emotions, attitudes and behaviors of patients in judging how they feel A purposive sample was taken using an approach that used stratified sampling technique to find out patients with a certain category of wound types for the purpose of accuracy and also certain demographic characteristics like age and gender . Participants had been chosen from one institute and were then interviewed after giving them a treatment for 10 days...
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