Research Article Critique on Alzheimer's Disease

Topics: Clinical trial, Alzheimer's disease, Research Pages: 7 (1720 words) Published: April 18, 2012
Danisha Stewart
April 18, 2012
Research Article Critique 1
NURS 4922

1. Brodaty, H., Ames, D., Snowdon, J., Woodward, M., Kirwan, J., Clarnette, R., & ... Greenspan, D. (2005). Risperidone for psychosis of Alzheimer's disease and mixed dementia: results of a double-blind, placebo-controlled trial. International Journal of Geriatric Psychiatry, 20(12), 1153-1157.

2. The purpose of this study is to evaluate the efficacy and safety of low dose risperidone in treating psychosis of Alzheimer’s disease (AD) and mixed dementia (MD) in a subset of nursing-home residents who had dementia and aggression and who were participating in a randomized placebo-controlled trail of risperidone for aggression.

3. The problem is clearly stated about treating patients with Alzheimer’s disease and mixed dementia with risperidone to decrease aggression.

4. The research problem is relevant to current clinical nursing practice because psychotic symptoms develop in about half of patients with AD during the course of their dementia and have been associated with increase disability, caregiver distress, and need for institutionalization.

5. In regard to the Literature review:
a. The author H. Brodaty et al. followed the format used in research articles. The article begins with an introduction about Alzheimer’s disease and mixed dementia and provides information about previous studies focusing on the heterogeneous groups of behavioral and psychological symptoms in general. The introduction section also included the current analysis, involving patients from another placebo-controlled study. The entire article was presented in sections that included the percentage of patients treated with risperidone, psychosis subscale scores from baseline to endpoint in patients with psychosis of AD and MD treated with risperidone or placebo. Also adverse events present in at least 10 patients diagnosed with psychosis of AD and MD treated with risperidone or placebo. This was followed by methods used to gather the information, a discussion which focused on the thesis and a conclusion.  b. I believe that the current state of knowledge about the topic was described fully in the article. The authors used a variety of research engines and sources to compliment the thesis. c. Yes, references are included from actual research studies and from theoretical works.

d. Yes, research study critiques are mentioned, but not critiqued.

e. There are no inconsistencies with what is known about the topic. The knowledge gap that exists about the topic is that risperidone does effectively reduce aggression in patients with AD and MD. f. No, the references are not current. 1996-2005

g. Did the researcher use mostly primary or secondary sources? Justify your answer. The research used mostly primary source some secondary sources were also used. The authors refer to other articles and studies that report new research finding. For example the author mentions the recent finding of the FDA sharing the results of a meta-analysis on overall mortality results for placebo controlled clinical trials including four other atypical antipsychotics in patients with dementia-related psychosis.

6. About the Organizing Framework:
a. Yes, this study does have an identified organizing framework, and there are several models present within the study depicted as charts and tables that explain information. b. At first glance the study seemed as though it was a theoretical framework because it had one theory base stating that studies have shown that when using risperidone patient with Alzheimer’s disease and mixed dementia reduce psychosis behavior and aggression. The study provided sources for this information as well. At second glance I noted the study to be one of conceptual framework because the research study is about evaluating the efficacy and safety of low-dose risperidone in treating psychosis of AD and MD. This is a...
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