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Quorum Sensing in Bacteria: Communication Equals Modification

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Quorum Sensing in Bacteria: Communication Equals Modification
Christal J. Thomas
November 7, 2010
BCMB 409/ Section 001
Professor: Tom Dockendorff

Bacteria: Communication Equals Modification

Bacteria are organisms that are extremely copious upon this planet. They are tiny and most are single celled organisms that can survive in just about any environment. Anywhere from plants to the human body is where these organisms can be discovered. Some of the strangest places that support bacterial life include places that have extremes of temperature. These bacteria are also very strange, much different from bacteria found living in and around humans. For example bacteria that live in extreme cold, like the North Pole, use methane as their substrates; and the ones that live in the deep sea use hydrogen sulphide. While most bacteria can live without oxygen (anaerobic bacteria) or whether they are aerobic bacteria that require oxygen. These particular bacteria use carbon-based sugars as main energy source. Even with so much diversity among bacteria, the most interesting part is how they communicate. Cell communication is a central mechanism in bacteria cells because it provides examples of parasitism relationship among different organisms such as S. aureus. It gives a means to control infections through a complex mechanism which is found in Pseudomonas aeruginosa. This touches on some variety of processes, including genetic transfer, antibiotic production growth and pathogenesis.

Many bacteria cells possess a unique communication system that allows them to exchange information within their own cell or among other cells. There have been recent studies about the communication among bacteria cells by using small molecules in order to communication with each other. These small molecules could consist of amino acid, peptide chains, or fatty acid derivatives. Moreover, these molecules aid the cells into exhibiting multi-cellular behaviors. The bacterium has the ability to sense diffusible signal molecules that are



Cited: Baldwin, Thomas O., Mary L. Treat and S. Colette Daubner. “Cloning and Expression of the luxY Gene from Vibrio fischeri Strain Y- 1 in Escherichia coli and Complete Amino Acid Sequence of the Yellow Fluorescent Protein.” Biochemistry 29 (1990):5509-5515. Bjarnsholt, Thomas and Michael Givskov. “The Role of Quorum Sensing in the Pathogenicity of the Cunning Aggressor Pseudomonas aeruginosa.” Anal Bioanal Cem 387 (2007):409-414. Cho, J.J., N.J. Panopoulos, and M.N. Schroth. “Genetic Transfer of Pseudomonas aeruginosa R Factors in Plant Pathogenic Erwinia Species.” Journal of Bacteriol 122.1 (1975):192–198 Devine, Jerry H., Cari Countryman, and Thomas O. Baldwin. “Nucleotide Sequence of the luxR and luxl Genes and Structure of the Primary Regulatory Region of the lux Regulon of Vibriofischeri ATCC 7744t.” Biochemistry 27 (1988): 837-842. Duan, Kangmin, Carol Dammel, Jeffrey Stein, Harvey Rabin and Michael G. Surette. “Modulation of Pseudomonas aeruginosa gene expression by Host Microflora through Interspecies Communication.” Molecular Microbiology 50.5 (2003): 1477-1491. Dunny, Gary M. and Betina A.B. Leonard. “Cell-Cell Communication in Gram-Positive Bacteria.” Annual Review of Microbiology 51 (1997):527-564. Lee Chan, Yong, Dennis J. O’Kane, and Edward A. Meighen. “Riboflavin Synthesis Genes Are Linked with the lux Operon of Photobacterium phosphoreum.” American Society for Microbiology 176.7 (1994): 2100-2104. Mel’Kina, O.E., I.V. Manukhov and G.B. Zavilgelsky. “The C-terminal domain of the Vibrio fischeri Transcription Activator LuxR is not Essential for Degradation by Lon Protease.” Cell Molecular Biology 44.3 (2010):454-457. Shadel, G.S. and Baldwin T.O. “The Vibrio-Fischeri LuxR Protein is Capable of Bidirectional Stimulation of Transcription and Both Positive and Negative regulation of the LuxR Gene.” 173.2 (1991): 568-574. Taga, Michiko E. and Bonnie L. Bassler. “Chemical Communication Among Bacteria.” Proceedings of the National Academy of Sciences 100 (2003): 14549-14554. Willey, Joanne M., Sherwood M. Linda and Christopher J. Woolverton. Prescott’s Principles of Microbiology. McGraw-Hill, 2002.

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