Project: Preparation and Recrystallisation of Aspirin

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Diploma in Applied Chemistry with Pharmaceutical Science

Organic Chemistry (CP4120/CP4502) Project
Preparation and Recrystallisation of Aspirin.


Name: XXXX
Class: DACP 1B/02
Admin no.: P1234567

Table of Contents
Page List of illustration iii Synopsis iv 1. Objective of experiment 1 2. Introduction 2.1Definition of aspirin 1 2.2 History of aspirin 1 2.3 Uses of aspirin 2 2.4 Side effect of aspirin 2 2.5 Functional group of aspirin 2 3.Theory 3.1 Recrystallisation 3 3.2 Esterification 3 4.Procedure 4.1 Preparation of aspirin 4 4.2 Recrystallisation of aspirin 4 5.Results and calculation 5 6.Discussion 6 7.Recommendation 7 8.Conclusion 7 Reference R-1

List of illustrations Page Figure 1: Willow bark 1 Figure 2: Charles Frederic Gerhardt 1 Figure 3: Felix Hoffman 1 Figure 4: Functional group of Aspirin 2


The aims of this experiment are to conduct the preparation of aspirin, perform recrystallisation to purify the compound using suction filtration and reinforce the skill of determination melting point of recrystallised compound. Aspirin is a crystalline compound derived from salicylic acid. It is widely used in assuagement of fever and as a wonderful painkiller and anti-inflammatory drug and, to prevent strokes and heart attacks. Esterification and recrystallisation are the two main process needed. Esterification which is the combination of a carboxylic acid and alcohol to form an ester, is involved in the synthesis of aspirin. Recrystallisation is a process of purifying solid organic compounds by the difference in solubility at different temperature.

The procedure is being separated into two parts, 1) Preparation of Aspirin and 2) Recrystallisation of Aspirin. 1, we...
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