Pilocarpine

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  • Topic: Atropine, Miosis, Dose
  • Pages : 2 (403 words )
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  • Published : December 2, 2012
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pilocarpine (Fig. 5), 0.45 mg. per kilogram
of atropine was administered intraperitoneally. Nine minutes after the atropine, the myopia had increased and then remained high until a larger dose of atropine, 0.8 mg. per kilogram, was given. The pupil contracted maximally during the experiment, and dilated only after the second dose of atropine. The remarkable fluctuations in refraction after 50 mg. per kilogram pilocarpine (Fig. 5) were not due topilocarpine (Fig. 5), 0.45 mg. per kilogram of atropine was administered intraperitoneally. Nine minutes after the atropine, the myopia had increased and then remained high until a larger dose of atropine, 0.8 mg. per kilogram, was given. The pupil contracted maximally during the experiment, and dilated only after the second dose of atropine. The remarkable fluctuations in refraction after 50 mg. per kilogram pilocarpine (Fig. 5) were not due to errors of measurements. Each point is in

fact the average of several readings in rapid
succession and there is no doubt that real
fluctuations of refraction took place. The
same is true for the dip at 11 minutes after
the first atropine dose. This was the only
monkey in the present series in which there
were such fluctuations and the only one
which showed this paradoxical effect on
refraction with pilocarpine and atropine.
Fluctuations in refraction have sometimes
been seen after systemic carbachol, and
with this drug the paradoxical effect on refraction is constantly noted after high doses.
6
Systemic effects of pilocarpine. The monkeys started to salivate after 0.1 mg. per kilogram of pilocarpine. At 0.5 to 1.0 mg.
per kilogram the salivation was profuse an
errors of measurements. Each point is in
fact the average of several readings in rapid
succession and there is no doubt that real
fluctuations of refraction took place. The
same is true for the dip at 11 minutes after
the first atropine dose. This was the only
monkey in the present series in which there...
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