WHITE kidney beans (Phaseolus vulgaris) is a member of the Leguminosae, tribe Phaseoleae, subfamily Papilionoideae. Cultivated forms are herbaceous annuals, which are determinate or indeterminate in growth habit. Phaseolus vulgaris L. was originally a crop of the New World, but is now grown extensively in all major continental areas. Its production spans from 52°N to 32°S latitude. It is a major source of dietary protein throughout both Latin America and Eastern Africa, but per capita consumption is declining as population increases outdistance production. Archeological investigations showed that Phaseolus vulgarisoriginated on the American Continent, specifically in southern United States, Mexico, Central America, and the northern part of South America. In particular, the species P. vulgaris was introduced into Europe in the sixteenth century and since then it has become a very important crop in many regions of the world.
Extracts of Phaseolus vulgaris (beans) are known to reduce glycaemia and food intake in rodents and humans. The present study evaluated the effects of a new, standardised and purified P. vulgaris extract (PVE), when employed as a supplement in a mixed balanced meal (60 % carbohydrates, 25 % lipids and 15 % protein), on glycometabolic and appetite control. To this end, a randomised, double-blind, placebo-controlled study was performed in twelve volunteers. Plasma glucose, insulin, C-peptide, ghrelin and satiety sensation ratings were assessed at baseline and during 3 h after meal consumption associated with PVE (100 mg) or placebo. Compared with placebo, PVE consumption resulted in lower increments in glucose (+15·4 (sem 5·4) v. 26·1 (sem7·3) %, P = 0·04 at 30 min), insulin (+981 (sem 115) v. 1325 (sem 240) %, P = 0·04 between 45 and 120 min) and C-peptide (+350 (sem 27) v. 439 (sem 30) %, P = 0·04 between 30 and 90 min). In the first 2 h, plasma ghrelin decreased similarly in both groups but did not rebound...
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