Virtual Pharmaceutical: How It Works
Our company name: Virtual Pharmaceutical
Drug name: VPL874C (Market name = Betatrix)
Possible indications = migraine prophylaxis, hypertension, coronary heart disease
Problem – want oral dosage form. - but has short half life (3-4hr)
Solution – oral dosage form with extended release which releases drug slowly so that the plasma concentrations are maintained at a therapeutic level for a prolonged period of time (usually between 8 and 12 hours).
Recent extended release formulations possible
pH-sensitive multiparticulate drug delivery system
- how it works: - a nano-suspension was made from with the drug, and then chitosan bead were made, which were degradable selectively in the colon
Advantage – area specific absorption of drug. And prevent drug form degradation, for non-soluble drugs
Disadvantage – not for water soluble drugs (have to make suspension), not for sustained release,
Modified Push-pull osmotic systems –
- how it works - the system has two compartments, one is hydrogel, and the other is for non-watersoluble drugs with orifice, which diffuses out with the hydrogel absorbs water and pushes the drug out slowly
Advantage – can use two drugs, one being water soluble can be incorporated into the expandable hydrogel. Sustained release.
Disadvantage – its better to use with two drugs, or no point of this, epensive,
Controlled drug diffusion for oral extened release by using micelle-forming properties and counter –charge polymer.
-how it works: - a highly water soluble drug was added to a gel forming polymer matrix but with a counter polymer which slows down drug diffusion out of the matrix
Advantage – for water soluble drugs, sustained release, simple to make
Disadvantage – not for all water soluble drugs, make sure that counter-charge polymer does not bind with too high affinity to the drug, and does not interact with the drug chemically. Our drug is not charged.
Aqueous-core microcapsules with a defined PLG
Drug name: VPL874C (Market name = Betatrix)
Possible indications = migraine prophylaxis, hypertension, coronary heart disease
Problem – want oral dosage form. - but has short half life (3-4hr)
Solution – oral dosage form with extended release which releases drug slowly so that the plasma concentrations are maintained at a therapeutic level for a prolonged period of time (usually between 8 and 12 hours).
Recent extended release formulations possible
pH-sensitive multiparticulate drug delivery system
- how it works: - a nano-suspension was made from with the drug, and then chitosan bead were made, which were degradable selectively in the colon
Advantage – area specific absorption of drug. And prevent drug form degradation, for non-soluble drugs
Disadvantage – not for water soluble drugs (have to make suspension), not for sustained release,
Modified Push-pull osmotic systems –
- how it works - the system has two compartments, one is hydrogel, and the other is for non-watersoluble drugs with orifice, which diffuses out with the hydrogel absorbs water and pushes the drug out slowly
Advantage – can use two drugs, one being water soluble can be incorporated into the expandable hydrogel. Sustained release.
Disadvantage – its better to use with two drugs, or no point of this, epensive,
Controlled drug diffusion for oral extened release by using micelle-forming properties and counter –charge polymer.
-how it works: - a highly water soluble drug was added to a gel forming polymer matrix but with a counter polymer which slows down drug diffusion out of the matrix
Advantage – for water soluble drugs, sustained release, simple to make
Disadvantage – not for all water soluble drugs, make sure that counter-charge polymer does not bind with too high affinity to the drug, and does not interact with the drug chemically. Our drug is not charged.
Aqueous-core microcapsules with a defined PLG