Pharmacodynamics (Drug Receptors)

Dose of drug administered
ABSORPTION

DISTRIBUTION

Drug in tissues

Drug in systemic circulation

Pharmacokinetics
Drug metabolized or excreted
ELIMINATION

Drug at site of action

Pharmacologic effect Pharmacodynamics Toxicity Efficacy

PHARMACOLOGY Pharmacodynamics
Actions of drug on the body  Specific to a drug/ class of drugs • Interaction with target sites (receptors/enzymes) • Effects at site of action • Dose-response relationship • Reduction in symptoms • Modification of disease process • Unwanted/side effects • Drug interactions • Inter- and intra-patient differences

Pharmacokinetics
Actions of body on the drug  Non-specific, general processes • Absorption from site of administration • Distribution to the site of action • Metabolism • Excretion • Onset of action • Duration of effect • Accumulation • Drug interactions • Inter- and intra-patient differences

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Study of biochemical and physiological effects of drugs and their mechanism of action

 Describes the actions of a drug  Includes the measurement of response to drugs and how response relates to drug dose or concentration

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Most drugs must bind to a receptor to bring about an effect

Therapeutic
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Toxic

Drug binding is only the 1st step in a complex sequence of events

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Lecture 1 Lecture 2

› Drug Receptors

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› Drug-Receptor Interaction

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Lecture 3

› Dose-Response Curve

What are Receptors?  Classification of receptors  Not all drugs have receptors
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Understand what receptors & their characteristics are’  Name and describe the classes of receptors.  Give an example of each class of receptors.  Understand that not all drugs require a receptor to work. Give examples of such drugs.
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Are usually proteins or part of a protein that have a distinct region to which drugs bind
→ 1.

produces a change that:
Directly induces a measurable response

2. Triggers a transduction chain that in turn produces a