Parkinsons term paper
Parkinson’s disease
Alisa R. Sewell
Collin County Community College at Preston Ridge
Parkinson's disease is characterized as a degenerative disorder of the central nervous system which is understood to persist and continually worsen over time. It is the second most common neurological disorder. Parkinson’s disease affects approximately one million people within the United States. This disorder progresses slowly and is unique in the sense that Parkinson’s disease can be caused by genetics among other things. Parkinson’s disease is well known for its characteristic tremors, stiffness, and difficulty with speech in the patients it affects.
Parkinson’s disease is caused by diminishment of the substantia nigra in the tegmentum which controls motor functions within the body. This disease is classified as a basil ganglionic disorder which causes a breakdown of dopamineric neurons in the substancia nigra, located in the midbrain. The substancia nigra is composed of neuromelanin which pigments the substancia nigra and gives it its darker characteristic. The neuromelanin also connects to the motor cortex which is responsible for one’s motor control and balance. The chemical dopamine is created in the substantia nigra. The basil ganglia receives inputs from the motor cortex, the association cortex, and the substancia nigra. The basil ganglia then sends messages to the motor cortex by way of the thalamus. With Parkinson’s disease, the nigral neurons are damaged, which causes the neuromelanin to be free to move into the adjacent tissue where it is phagocytosed and moved away by macrophages. This degenerative process not only destroys the process of creating dopamine, but it also causes the pigmentation of the substancia nigra to change and become lighter in appearance. The lack of dopamine-related input from the substantia nigra negatively changes the equilibrium of the output from the basil ganglia to the motor cortex. This alteration in the equilibrium
Alisa R. Sewell
Collin County Community College at Preston Ridge
Parkinson's disease is characterized as a degenerative disorder of the central nervous system which is understood to persist and continually worsen over time. It is the second most common neurological disorder. Parkinson’s disease affects approximately one million people within the United States. This disorder progresses slowly and is unique in the sense that Parkinson’s disease can be caused by genetics among other things. Parkinson’s disease is well known for its characteristic tremors, stiffness, and difficulty with speech in the patients it affects.
Parkinson’s disease is caused by diminishment of the substantia nigra in the tegmentum which controls motor functions within the body. This disease is classified as a basil ganglionic disorder which causes a breakdown of dopamineric neurons in the substancia nigra, located in the midbrain. The substancia nigra is composed of neuromelanin which pigments the substancia nigra and gives it its darker characteristic. The neuromelanin also connects to the motor cortex which is responsible for one’s motor control and balance. The chemical dopamine is created in the substantia nigra. The basil ganglia receives inputs from the motor cortex, the association cortex, and the substancia nigra. The basil ganglia then sends messages to the motor cortex by way of the thalamus. With Parkinson’s disease, the nigral neurons are damaged, which causes the neuromelanin to be free to move into the adjacent tissue where it is phagocytosed and moved away by macrophages. This degenerative process not only destroys the process of creating dopamine, but it also causes the pigmentation of the substancia nigra to change and become lighter in appearance. The lack of dopamine-related input from the substantia nigra negatively changes the equilibrium of the output from the basil ganglia to the motor cortex. This alteration in the equilibrium