Paracetamol Preperation

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Paracetamol - a curriculum resource
Frank Ellis

RSeC
ROYAL SOCIETY OF CHEMISTRY

Paracetamol - a curriculum resource
Compiled by Frank E llis
Edited by Colin Osborne and Maria Pack
Designed by lmogen Bertin
Published by the Royal Society of Chemistry
Printed by the Royal Society of Chemistry
Copyright 0 Royal Society of Chemistry 2002
Registered charity No. 207890
Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the U K Copyright Designs and Patents Act, 1988, this publication may not be reproduced, stored, or transmitted, in any form or by any means, without the prior permission in writing of the publishers, or in the case of reprographic reproduction, only in accordance with the terms of the licences issued by the Copyright Licensing Agency in the UK, or in accordance with the terms o licences f

issued by the appropriate Reproduction Rights Organisation outside the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the Royal Society of Chemistry at the London address printed on this page.

Notice to all U K Educational Institutions. The material in this book may be reproduced by photocopying for distribution and use by students within the purchasing institution providing no more than 50% of the work i s reproduced in this way for any one purpose. Tutors wishing to reproduce material beyond this f

limit or to reproduce the work by other means such as electronic should first seek the permission o the Society.
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ISBN 0-85404-375-6
British Library Cataloguing in Publication Data.
A catalogue for this book i s available from the British Library

Contents
H o w to use this book ................................................................................................

2

Background information ...........................................................................................

3

Paracetamol i s a c ommon compound .......................................................................

3

The history of paracetamol ........................................................................................

3

Experimental and investigation section .....................................................................

6

The extraction and purification of paracetamol from tablets ......................................

6

Paracetamol form u I at ions : presentat ion activity ........................................................

7

The preparation of paracetamol ................................................................................ 8 Step 1 . nitration of phenol ................................................................................. 9 the

Step 2 . reduction of a n itro group to an amine ................................................. 11 the
Step 3 . formation of an amide ......................................................................... t he
12
The quantitative andysis of various formulations of paracetamol ............................

13

Using thin-layer chromatography to investigate the reactions ..................................

15

Teachers’ note.$ .......................................................................................................

18

The...
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