Jose Arcadio Buendia is forced to kill a man who insulted his wife Ursula and is forced to move away from his town. The murder will chase him for one hundred years as a curse, though. He's scared of this, nevertheless he goes through fantastic lands and jungles until he spots a new place to establish and found Macondo.
Macondo turns into a place for merchant gypsies to arrive and bring the most recent 'discoveries' such as ice and magnet. One of them, Melquiades, visits Jose Arcadio and promotes the study of alchemy. Jose Arcadio goes mad and as he intensifies this learning, strange events --presumably from the curse--begin to isolate Macondo from the rest of the country, such as an epidemic that make people forget what they just did or saw.
As these events unfold, Jose Arcadio's wife gives birth to many children, and each of them is given their own story, but finally all of them are linked by the same curse of living in solitude.
This book follows one hundred years of the Buendia family's rise and fall in the fictional town of Macondo. The patriarch of the Buendias, Jose Arcadio, founds the town by accident with his wife, Ursula. Together they ignite four generations of Buendias that struggle to exist in the real world, and all ultimately fail. Each member of the Buendia family, in every generation, deals with his or her own version of solitude. Some choose solitude, some are destined to it.
The Buendia race comes to an end with its final member, the last Aureliano, being swept up in a hurricane of biblical proportions, and the reader is left wondering whether Macondo could really have existed somewhere or everywhere in time.
One Hundred Years of Solitude is a story about an isolated family, The Buendias, in an imagined viallage,Macondo, somewhere in Latin America, probably Colombia.For One hundred years or more,the village has been alienated without any contact with the outside world, except for gypsies...