Neoplasia
NEOPLASIA
Presented by Dr Abudu Emmanuel Kunle (MBBS, M.Sc, FMCPath) Senior Lecturer and Consultant Histopathologist University of Uyo Teaching Hospital,Uyo, Akwa- Ibom State, Nigeria.
Neoplasia means the process of new growth whilst Neoplasm means a new growth. Sometimes, the parenchyma cells stimulate the formation of an abundant collagenous stroma, referred to as desmoplasia. Some tumours e.g. some cancers of breast are stony hard or scirrhous. Sarcomas have little connective tissue stroma and so are fleshy. Pseudo tumours: i) An ectopic rest of normal tissue is sometimes called a choristoma e.g a rest of adrenal cells under the kidney capsule or a pancreatic nodular rest in the mucosa of the small intestine may mimic neoplasm.
NEOPLASIA:INTRODUCTION
NEOPLASIA:INTRODUCTION contd
Ii) Hamartoma = a mass of disorganized but mature specialized cells or tissue indigenous to the particular site e.g. a hamartoma in the lung may contain islands of cartilage, blood vessels, bronchial-type structures, & lymphoid tissue and sometimes, the lesion is purely cartilaginous or purely angiomatous. A true tumour could be benign or malignant This is subclassified into epithelial or mesenchymal in origin. Other types: lymphoma, melanoma Epithelial: non glandular (squamous, transitional,papilloma Glandular(adenoma/ adenocarcinoma Seminoma tends to spread to lymph node along the iliac artery and aorta and highly radiosensitive i.e. responds well to radiotherapy. Embryonic carcinoma of the testis is not radiosensitive and tends invade locally beyond the confines of the testis and spread throughout the body
a) Biology of tumour growth: Benign and malignant neoplasms
The nature history of most malignant tumours can be divided into 4 phases: 1) malignant change in the target cell (transformation); 2) growth of the transformed cells; 3) local invasion; and 4) distant metastases. Differentiation refers to the extent to which neoplastic cells resemble comparable normal cells, both
Presented by Dr Abudu Emmanuel Kunle (MBBS, M.Sc, FMCPath) Senior Lecturer and Consultant Histopathologist University of Uyo Teaching Hospital,Uyo, Akwa- Ibom State, Nigeria.
Neoplasia means the process of new growth whilst Neoplasm means a new growth. Sometimes, the parenchyma cells stimulate the formation of an abundant collagenous stroma, referred to as desmoplasia. Some tumours e.g. some cancers of breast are stony hard or scirrhous. Sarcomas have little connective tissue stroma and so are fleshy. Pseudo tumours: i) An ectopic rest of normal tissue is sometimes called a choristoma e.g a rest of adrenal cells under the kidney capsule or a pancreatic nodular rest in the mucosa of the small intestine may mimic neoplasm.
NEOPLASIA:INTRODUCTION
NEOPLASIA:INTRODUCTION contd
Ii) Hamartoma = a mass of disorganized but mature specialized cells or tissue indigenous to the particular site e.g. a hamartoma in the lung may contain islands of cartilage, blood vessels, bronchial-type structures, & lymphoid tissue and sometimes, the lesion is purely cartilaginous or purely angiomatous. A true tumour could be benign or malignant This is subclassified into epithelial or mesenchymal in origin. Other types: lymphoma, melanoma Epithelial: non glandular (squamous, transitional,papilloma Glandular(adenoma/ adenocarcinoma Seminoma tends to spread to lymph node along the iliac artery and aorta and highly radiosensitive i.e. responds well to radiotherapy. Embryonic carcinoma of the testis is not radiosensitive and tends invade locally beyond the confines of the testis and spread throughout the body
a) Biology of tumour growth: Benign and malignant neoplasms
The nature history of most malignant tumours can be divided into 4 phases: 1) malignant change in the target cell (transformation); 2) growth of the transformed cells; 3) local invasion; and 4) distant metastases. Differentiation refers to the extent to which neoplastic cells resemble comparable normal cells, both