MUGA ppt

Multi-Gated
Acquisition
Scan

Objectives:
 What is a MUGA Scan
 Clinical Indications When Performing







Procedure
Radiopharmaceuticals Used For Imaging
Mechanism of Localization of
Radiopharmaceutical
Patient Preparation
Imaging Protocols
Image Findings
Technical Considerations

Multi-Gated Acquisition Scan
(MUGA)
Is a nuclear medicine test that uses a radioactive isotope called a tracer to access how well the human heart is pumping blood

Multi-Gated Acquisition Scan
MUGA Scan
Also known as:
 Gated Blood Pool Imaging
 Radionuclide Angiography (RNA)
 Radionuclide Ventriculography (RVG,
RNV)
 Myocardial Perfusion Imaging (MPI)
 Nuclear Stress Test
 Synchronized Multi-gated Acquisition
(SYMA) scan

 Dr. Myron Prinzmetal in 1948-- 1st attempt to









use radiotracers to assess cardiac function
First agent used 1964-99mTc human serum albumin 1970’s, in-vitro & in-vivo methods established
Evaluates the Hearts Pumping Mechanism
Most Accurate
Non-Invasive
Reproducible
Performed in hospital or outpatient facility
No down time

Ejection Fraction (EF)
Ejection fraction (%) = [ED (net) – ES (net)] ÷
ED x 100
 The percentage of blood that is pumped out of the

hearts left ventricle with each heartbeat.
 Demonstrates how well the heart is working
 Left Ventricle: 50-80%
 Right Ventricle: 45%

Ejection Fraction (EF)

Normal EF
(Curve)
65%

Abnormal EF
(Flat)
41%

EF of 70%

MUGA Scan Images

* The two upper panels show scan images of the left ventricle: (a) just before it pumps blood
(b) just after it is done pumping blood
(but before it begins to fill with blood again). * The two lower panels show diagrams that represent:
(c) the ejection fraction
(d) the wall motion of the left ventricle.

Blood Flow

Mechanism of Localization:
 Damaged Myocyte (infarction) leads






to loss of cell membrane
Influx of calcium
Formation of Calcium Phosphate
Complexes
Sites for Tc99m Pyrophosphate uptake Highest uptake at periphery on