Monoclonal Antibody Production

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Monoclonal Antibody Production

A Report of the Committee on Methods of Producing Monoclonal Antibodies Institute for Laboratory Animal Research National Research Council

NATIONAL ACADEMY PRESS Washington, DC 1999

NATIONAL ACADEMY PRESS

2101 Constitution Avenue, NW

Washington, DC 20418

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This study was supported by Contract No. N0-OD-4-2139 between the National Academy of Sciences and the National Institutes of Health. Any options, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the organizations or agencies that provided support for the project. Monoclonal Antibody Production: A Report of the Committee on Methods of Producing Monoclonal Antibodies, Institute for Laboratory Animal Research, National Research Council.

Copyright 1999 by the National Academy of Sciences. All rights reserved.

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COMMITTEE ON METHODS OF PRODUCING MONOCLONAL ANTIBODIES
Peter A. Ward (Chair), Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan Jane Adams, Juvenile Diabetes Foundation, Washington, DC Denise Faustman, Immunology Laboratories, Massachusetts General Hospital, Charlestown, Massachusetts Gerald F. Gebhart, Department of Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa James G. Geistfeld, Laboratory Animal Medicine, Taconic Farms, Germantown, New York John W. Imbaratto, Cell Culture Manufacturing, Covance Biotechnology Services, Inc., Research Triangle Park, North Carolina Norman C. Peterson, Department of Clinical Studies, University of Pennsylvania, Philadelphia, Pennsylvania Fred Quimby, Center for Laboratory Animal Resources, Cornell University Veterinary College, Ithaca, New York Ann Marshak-Rothstein, Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts Andrew N. Rowan, Humane Society of the United States, Washington, DC Matthew D. Scharff, Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York Staff Ralph B. Dell, Director

Kathleen A. Beil, Administrative Assistant
Susan S. Vaupel, Managing Editor, ILAR Journal
Marsha K. Williams, Project Assistant
Norman Grossblatt, Editor

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Institute for Laboratory Animal Research Council
John VandeBerg (Chair), Southwest Foundation for Biomedical Research, San Antonio, Texas Christian R. Abee, Department of Comparative Medicine, University of South Alabama, Mobile, Alabama Bennett Dyke, Southwest Foundation for Biomedical Research, San Antonio, Texas Rosemary W. Elliott, Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York Gerald F. Gebhart, Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, Iowa Hilton J. Klein, Department of Laboratory Animal Resources, Merck Research Laboratories, West Point, Pennsylvania Margaret Landi, Department of Laboratory Animal Science, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania Charles R. McCarthy, Kennedy Institute of Ethics, Georgetown University, Washington, DC Harley Moon, Veterinary Medical Research Institute, Iowa State University, Ames, Iowa William Morton, Regional Primate Research Center, University of Washington, Seattle, Washington Robert J. Russell, Harlan Sprague Dawley, Inc., Indianapolis, Indiana William S. Stokes, Animal and Alternative Resources, National Institute of Environmental Health Science, Research Triangle Park, North Carolina John G. Vandenbergh, Department of Zoology, North Carolina...
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