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This article was downloaded by: [Jawaharlal Nehru Technological University] On: 01 May 2013, At: 23:14 Publisher: Taylor & Francis Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK

Phosphorus, Sulfur, and Silicon and the Related Elements
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The Synthesis of Some New Sulfur Heterocyclic Compounds as Potential Radioprotective and Anticancer Agents M. M. Ghorab , A. N. Osman , E. Noaman , H. I. Heiba & N. H. Zaher a a a a b c

Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt b

Department of Organic Chemistry, Cairo University, Giza, Egypt c

Department of Radiation Biology, National Center For Radiation Research and Technology, Nasr City, Cairo, Egypt Published online: 01 Feb 2007.

To cite this article: M. M. Ghorab , A. N. Osman , E. Noaman , H. I. Heiba & N. H. Zaher (2006): The Synthesis of Some New Sulfur Heterocyclic Compounds as Potential Radioprotective and Anticancer Agents, Phosphorus, Sulfur, and Silicon and the Related Elements, 181:8, 1935-1950 To link to this article: http://dx.doi.org/10.1080/10426500500544014

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Phosphorus, Sulfur, and Silicon, 181:1935–1950, 2006 Copyright © Taylor & Francis Group, LLC ISSN: 1042-6507 print / 1563-5325 online DOI: 10.1080/10426500500544014

The Synthesis of Some New Sulfur Heterocyclic Compounds as Potential Radioprotective and Anticancer Agents Downloaded by [Jawaharlal Nehru Technological University] at 23:14 01 May 2013 M. M. Ghorab

Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt

A. N. Osman
Department of Organic Chemistry, Cairo University, Giza, Egypt

E. Noaman
Department of Radiation Biology, National Center For Radiation Research and Technology, Nasr City, Cairo, Egypt

H. I. Heiba
Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt

N. H. Zaher
Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt

Some novel 5-subistituted amino-3-methylthiophene-2,4-dicarboxylic acid diethyl ester (3–6), 3,5-dimethyl-4-oxo-2-thioxo-1,2,3,4-tetra-hydro-thieno[2,3-d]pyrimidine (7), imidazothienopyrimidene (8), and 1,2,4-triazolo-thienopyrimidine (11) were synthesized via a reaction of the isothiocyanate 2 with different reagents. The identification of the new compounds was established by elemental analysis, and IR, 1 H NMR, and mass spectral data. Some prepared compounds were tested for their radioprotective and anticancer activities. Compounds 7 and 16 showed significant activities against EAC cells, while compound 5 exhibited radioprotective activity. Keywords Radioprotective and anticancer activities; thieno[2,3-d]pyrimidines

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