Kawasaki Disease

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Kawasaki disease
Mucocutaneous lymph node syndrome; Infantile polyarteritis
Last reviewed: June 20, 2011.
Kawasaki disease is a rare condition in children that involves inflammation of the blood vessels. Causes, incidence, and risk factors
Kawasaki disease occurs most frequently in Japan, where the disease was first discovered. In the United States, after congenital heart defects, Kawasaki disease is the leading cause of heart disease in children. Most of these patients are younger than age 5. The disease occurs more often in boys than in girls. Kawasaki disease is a poorly understood illness. The cause has not been determined. It may be an autoimmune disorder. The disorder affects the mucus membranes, lymph nodes, walls of the blood vessels, and the heart. Kawasaki disease can cause inflammation of blood vessels in the arteries, especially the coronary arteries. This inflammation can lead to aneurysms. An aneurysm can lead to a heart attack, even in young children, although this is rare. Symptoms

Kawasaki disease often begins with a high and persistent fever greater than 102 °F, often as high as 104 °F. A persistent fever lasting at least 5 days is considered a classic sign. The fever may last for up to 2 weeks and does not usually go away with normal doses of acetaminophen (Tylenol) or ibuprofen. Other symptoms often include:

* Extremely bloodshot or red eyes (without pus or drainage) * Bright red, chapped, or cracked lips
* Red mucous membranes in the mouth
* Strawberry tongue, white coating on the tongue, or prominent red bumps on the back of the tongue * Red palms of the hands and the soles of the feet
* Swollen hands and feet
* Skin rashes on the middle of the body, NOT blister-like * Peeling skin in the genital area, hands, and feet (especially around the nails, palms, and soles) * Swollen lymph nodes (frequently only one lymph node is swollen), particularly in the neck area * Joint pain and swelling, frequently on...
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