Lohit Pindoria - Pharmacy Interview Questions – Drug Development Pharmacology: Pharmacodynamics (depressing, stimulating, cytotoxicity, irritation, replacing substances) Pharmacodynamics (The action of the drug on the body) Desired activity The desired activity of a drug is mainly due to one of the following:
Undesirable effects Cellular membrane disruption Chemical reaction Interaction with enzyme proteins Interaction with structural proteins Interaction with carrier proteins Interaction with ion channels Ligand binding to receptors: o Hormone receptors o Neuromodulator receptors o Neurotransmitter receptors Pharmacokinetics (The action of the body on the drug)
Increased probability of cell mutation (carcinogenic activity) A multitude of simultaneous assorted actions which may be deleterious Interaction (additive, multiplicative, or metabolic) Induced physiological damage, or abnormal chronic conditions
Liberation - the process of release of drug from the formulation. Absorption - the process of a substance entering the blood circulation. Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body. Metabolism - the irreversible transformation of parent compounds into daughter metabolites. Excretion - the elimination of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue, renal or hepatic metabolism (break down in active and for extractive).
Pharmacokinetics describes how the body affects a specific drug after administration. Pharmacokinetic properties of drugs may be affected by elements such as the site of administration and the dose of administered drug. These may affect the absorption rate.
Please talk about a current controversial issue regarding pharmacy, and your personal opinion towards it. Contraceptives: Religion and Morals of Pharmacist Can you tell me about a controversial drug in the media? FDA accused of being in contempt of court as they failed to reconsider restrictions on Plan B ((Levonorgestrel). The FDA said it would allow sale of Plan B without a prescription to all women 17 and older. But the agency said it would not make it available to younger women unless it received a request to do so from the company. Plan B consists of higher doses of a hormone found in many standard birth-control pills. Taken within 72 hours of unprotected sex, it has been shown to be highly effective at preventing pregnancy. But the medication has long been controversial. Some anti-abortion activists argue that the drug can cause the equivalent of an abortion in some cases by making the womb inhospitable to an embryo -- a claim disputed by many medical experts and reproductive rights activists. Why is organic chemistry important to pharmacy? Interaction of different chemical compound, how compounds choose to react, why compounds exist as they do Which science is most important in pharmacy and why? Chemistry, the study of chemical compounds and there mechanisms of actions What do you enjoy about the courses which you are currently doing? Organic chemistry, how compound have certain behaviours and preferences of reactions Do you know anything about any common drugs (e.g. NSAIDS and Paracetamol), how they are made, how the work within the body, issues with the drug? Aspirin (an NSAIDS), (C9H8O4), analgesic (painkiller), antipyretic (reduce fever), anti-inflammatory, Aspirin also has an antiplatelet effect by inhibiting the production of thromboxane, which under normal circumstances binds platelet molecules together to create a patch over damage of the walls within blood vessels. Because the platelet patch can become too large and also block blood flow, locally and downstream, aspirin is also used long-term, at low doses, to help prevent heart attacks, strokes, and blood clot formation in people at high risk for developing blood clots. It has also been established that low doses of aspirin...
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