Importance of Peroxisomal Proteins in the Human Body

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Cell Bio Bites Topic: Peroxisomes

The Importance of Peroxisomal Proteins in the Human Body

By:
Jeffrey Palumbo
20523300

For
BIOL 130 Tutorial Section 116
Shirley Chan

The Importance of Peroxisomal Proteins in the Human Body
Peroxisomes are small organelles found in almost all eukaryotic cells that contain a variety of enzymes and are responsible for an assortment of essential metabolic processes (Wanders, 2013). Generally, these processes include the β-oxidation of fatty acids and the detoxification of reactive oxygen and nitrogen species. In order for these reactions to occur, housekeeping functions are performed by peroxisomal proteins (Stanley & Williams, 2010). In general, peroxisomal proteins are important to the human body because they play a key role in peroxisome biogenisis and if the proteins misfolds this can lead to serious disorders. Firstly, peroxisomal proteins are important to the human body because they play a vital role in peroxisome biogenesis. Peroxisome biogenesis consists of the formation of the peroxisomal membrane, import of proteins into the peroxisomal matrix and the proliferation of organelles (Eckert & Erdmann, 2003). The peroxisomal proteins that regulate peroxisome biogenesis are called peroxins. An important peroxin is Peroxin 5, also called Pex5p. This protein undergoes a cycle that involves: cargo recognition, membrane docking, cargo release and recycling (Stanley & Williams, 2010). The cargo for Pex5p are proteins containing a peroxisome targeting signal one or PTS1 (Hawkins et al., 2007). After binding to the PTS1, Pex5p brings the protein back to the peroxisome, deposits it and then goes back into the cytosol of the cell to repeat the cycle. This cycle allows the peroxisome to keep functioning (Stanley & Williams, 2010). The peroxisomes are important to a cell and peroxisomal proteins play an important role in keeping peroxisomes functioning. Secondly, there are many disorders and diseases that are...
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