Immunology

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85326 Lecture 5

Role of transmembrane signaling in immunorecognition (signal transduction)
G Ligand
(primary
0 messenger)
0.0

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binding

CYTOSOL
Cellular responses
Signal transduction (via second messengers)
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Copyri qht cD 2005 Pearson Education, Inc. publi shinq as Benjam i n Cum m inq s O
0

GROWTH

SIGNAL TRANSDUCTION

SURVIVAL DIFFERENTIATION

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PROLIFERATION

Membrane Receptor Classes
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Ligand binding opens or closes the channel.
Extracellular
signal
/'" molecules
(') \
Receptor C7
region

ECF
G proteln-coupreceptor
"'V Integrin
Ligand binding to a receptor-enzyme activates an intracellular enzyme ..

Ugand binding to a G protein- l coupled receptor opens an ion channel or alters enzyme activity. Ligand binding to ICF
integrin receptors
aHers the cytoskeleton.
F our classes of membrane receptors

DISTRIBUTION OF MOLECULAR FUNCTIONS OF 26,383 HUMAN GENES_ % OF TOTAL GENE NUMBER_ 42% UNKNOVVN FUNCTION...
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