Immune System

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  • Topic: Immune system, Adaptive immune system, Innate immune system
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  • Published : June 11, 2011
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Immune system
From Wikipedia, the free encyclopedia

A scanning electron microscope image of a single neutrophil (yellow), engulfing anthraxbacteria (orange). An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killingpathogens and tumor cells. It detects a wide variety of agents, from viruses to parasitic worms, and needs to distinguish them from the organism's own healthy cells and tissues in order to function properly. Detection is complicated as pathogens can evolve rapidly, producing adaptations that avoid the immune system and allow the pathogens to successfully infect their hosts. To survive this challenge, multiple mechanisms evolved that recognize and neutralize pathogens. Even simple unicellular organisms such as bacteriapossess enzyme systems that protect against viral infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include antimicrobial peptides called defensins, phagocytosis, and thecomplement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms.[1] The typical vertebrate immune system consists of many types of proteins, cells, organs, and tissues that interact in an elaborate and dynamic network. As part of this more complex immune response, the human immune system adapts over time to recognize specific pathogens more efficiently. This adaptation process is referred to as "adaptive immunity" or "acquired immunity" and creates immunological memory. Immunological memory, created from a primary response to a specific pathogen, provides an enhanced response to secondary encounters with that same, specific pathogen. This process of acquired immunity is the basis of vaccination. Primary response can take 2 days and up to 2 weeks to develop. After the body gains immunity towards a certain pathogen, when infection by that pathogen occurs again, the immune response is called the secondary response. Disorders in the immune system can result in disease, including autoimmune diseases, inflammatory diseases and cancer.[2] [3] Immunodeficiencydiseases occur when the immune system is less active than normal, resulting in recurring and life-threatening infections. Immunodeficiency can either be the result of a genetic disease, such as severe combined immunodeficiency, or be produced by pharmaceuticals or an infection, such as the acquired immune deficiency syndrome (AIDS) that is caused by the retrovirus HIV. In contrast, autoimmune diseases result from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and lupus erythematosus.Immunology covers the study of all aspects of the immune system, having significant relevance to health and diseases. Further investigation in this field is expected to play a serious role in promotion of health and treatment of diseases. -------------------------------------------------

[edit]History of immunology
For more details on this topic, see History of immunology.

Paul Ehrlich
Immunology is a science that examines the structure and function of the immune system. It originates from medicine and early studies on the causes of immunity to disease. The earliest known mention of immunity was during the plague of Athens in 430 BC. Thucydides noted that people who had recovered from a previous bout of the disease could nurse the sick without contracting the illness a second time.[4] In the 18th century, Pierre-Louis Moreau de Maupertuis made experiments with scorpion venom and observed that certain dogs and mice were immune to this venom.[5] This and other observations of acquired immunity was later exploited by Louis Pasteur in his development of vaccination and his...
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