Hypoglycemic Effect of Musa Sapientum on Alloxan-Induced Diabetic Rats and the Resultant Effect of Ast Activity in Brain and Heart

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Hypoglycemic Effect of Methanolic Extract of Musa Sapientum Sucker, in Alloxan-Induced Diabetic Rats, and Its Relative Effect on Aspartate Transaminase in Activity in Brain and Heart

Oseni Kehinde Ajibola|
April 2008|

ABSTRACT
Musa sapientum is an herb used in Nigeria folklore for the treatment of diabetes mellitus. The sucker part of the plant was used for this experiment and the blood glucose level, weight and AST activity was determined in Musa sapientum treated diabetic rats and normal rats. Oral administration of Musa sapientum sucker showed significant decrease in blood glucose level in alloxan induced diabetic rats at 5mg and 10mg\kg body weight concentrations (78.33±12.70 and 63.0±3.57 respectively) compared with untreated diabetic rats (252.20±26.19). The weight losses of the rats were also restored after treatment with this plant. In the brain, there was a high significant difference between the administered herb i.e. Musa sapientum at both concentrations 5mg and 10mg (24.33±3.55 and 19.81±3.28 respectively) compared to the control group (38.87±4.58). When compared with the glibenclamide group, there was a significant difference (p<0.05) between Musa sapientum group (24.33±3.55 for 5mg and 19.81±3.28 for 10mg) and the glibenclamide treated rats (49.99±4.58). However the activity was higher at 10mg concentration than the 5mg group. In the heart, it was observed that at (p<0.05), there was slight significant difference between the control (28.87±2.82), the 5mg (25.55±3.95) and 10mg\kg body weight group (24.33±3.55). When compared with glibenclamide (38.86±4.58) at (p<0.05) there was high significant difference between Musa sapientum group [5mg (25.55±3.95), 10mg (24.33±3.55)] and it. Conclusively, based on the above values, Musa sapientum sucker has a positive effect on AST activity in the organs stated above compared to glibenclamide.

LIST OF TABLES
TABLE 1: Showing differential changes in the fasting blood sugar in different rat groups for four weeks. TABLE 2: Showing the activity of AST (U/L) in brain of the various rat groups. TABLE 3: Showing the activity of AST (U/L) in heart of the various rat groups.

CHAPTER ONE
1.0 INTRODUCTION
Herbs in form of leaves, barks, stems, flowers of plants have generally been known to be medicinal. Although some have been used as source of food, but what is generally attributed to herbs is their phytochemical properties. Locally, herbs have been used for treatment of various diseases without any scientific basis. They are just used due to natural instinct and inheritance i.e. a particular remedy for diseases been passed on from one generation to another. The herbs are collected at various times of the day but commonly in the evening when supposedly the effect is high. The herbs are processed in various forms; some are cut into small pieces and soaked with water or alcohol in a bottle and sometimes are soaked with soft drinks (7up) with the aim extracting its important parts for healing. Some herbs (leaves and flowers) are mashed into powdery form after they are sun-dried and then used with food in form of fluid (pap, ogi in Yoruba). Some are superstitious placed around the waist, entrances, underneath their beds etc hoping that they will serve some healing purposes. But with scientist (biochemist, pharmacologist, microbiologist etc.) working extensively on herbs, various discoveries have been made showing the wide range of therapeutic values and effects of these herbs. Diabetes on the other hand refers to a condition in which the pituitary gland increases urinary output (diabetes insipidus) or a disorder in which the pancreas produces defects in insulin production or action, thus inducing hyperglycemia (diabetes mellitus). [Stedman’s Medical Dictionary, (2006)] Due to increasing prevalence of diabetes in the world and mostly in the developed countries, a lot of researches have been done to check for the effect of herbs on diabetes and...
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