Huntington's Disease

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  • Topic: Huntington's disease, Disease, Huntingtin
  • Pages : 5 (1357 words )
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  • Published : January 19, 2011
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This paper sheds light on one of the most important diseases which is Huntington’s disease
(HD). It’s widely spread around the world but it’s not commonly known among people. Since
science developed and genetics became known, scientists discovered that HD is inherited from

one generation to another which have put the scientists with a big challenge to find cure for such

disease. In addition, this paper provides information about causes, symptoms, inheritance,

treatments & a test for Huntington’s disease. My aim from this research is to introduce such a

disease for people, to make it familiar to them & to prepare them to know how to deal with it

once they face it.

Huntington’s disease


Diseases are the serious problems that the world is facing, not from nowadays but from the old centuries. Now, scientists have discovered hundreds of diseases, some of them are simple and others are fatal. Also, as the science developed and genetics became known, scientists discovered that many diseases are inherited from one generation to another which have put the scientists with a big challenge to find cure for such diseases. One of these diseases is called "Huntington's disease".

What is Huntington's disease?
Area of the brain damaged by HD (shown in purple) Huntington's disease is a brain disorder, mainly affecting the brain and spinal cord that destroys cells in the part of the brain that controls movement, emotion, and thought process. This part of the brain is called the basal ganglia. Moreover, Huntington's disease is a hereditary disease, which means that it is inherited from one generation to another. In 1872, Dr. Georges Huntington became the first to publish a detailed description of the disease that has become linked with his name. In the past there were many names for Huntington’s disease. One of its earliest names was "Chorea" (uncontrollable movements).Other descriptive names were evolved: "Hereditary chorea" which emphasizes how the disease is passed from parent to child and "Chronic progressive chorea" which shows how the symptoms of the disease worsen over time. Today, physicians are using the simple term "Huntington's disease" (HD). In general, the duration of the illness ranges from 10 to 30 years. Country/Region Extrapolated Prevalence Population Estimated Used Lebanon


What causes Huntington's disease?
Huntington's disease is caused by a mutation in a gene on chromosome 4. It is caused by the length of a repeated section of a gene exceeding the normal range. The Huntingtin gene (HTT) normally provides the information to produce Huntingtin protein, but when affected, it produces mutant Huntingtin (mHTT) instead. THuntingtin Protein that causes problems leading to Huntington's disease is located on chromosome 4.

Symptoms of Huntington's disease occur gradually and can start at any age, but it is more common to show in a person in his mid-forties. The disease is usually recognized when physical symptoms occur, but at this point they are usually accompanied by unrecognized cognitive symptoms which refer to brain processes such as thinking, attention, perception, etc…, and psychiatric ones. Almost everyone with Huntington's disease eventually exhibits all physical symptoms, but cognitive and psychiatric symptoms can vary significantly among individuals.

-Physical Symptoms:-
The most characteristic physical symptoms are jerky, random, and chorea (uncontrollable movements). As the disease progresses, any function that requires muscle control is affected, causing physical instability, abnormal facial expression, difficulties in chewing, swallowing, and eating difficulties which commonly cause weight loss and may lead to...
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