Hodgkin's Disease
Hodgkin 's diseaseGuerline Baptiste
Chamberlain School of Nursing
Pathophysiology
J. Dobrzyn
May 31, 2013
Hodgkin 's Disease
In 1832 Thomas Hodgkin described a progressively fatal condition characterized by enormous lymph node swelling that he believed to be one disease. Characteristic cells involved in this disease were identified microscopically by Sternberg and Reed in 1898 and 1902, respectively. The identification of these cells, now known as Reed-Sternberg cells, allowed for the initial classification of Hodgkin 's disease. In the past two decades advances in histology and immunohistology have revealed that the Reed-Sternberg cell is B-cell lineage, and that Hodgkin 's disease is not a single cell, but instead two separate diseases. Hodgkin 's disease. The four stages of Hodgkin 's disease are based on factors such as location, whether cancer is found in more than one group of lymph nodes, or on one or both sides of the diaphragm. The potential curability of Hodgkin 's disease was first recognized in 1920, when patients with localized tumor with radiation were shown to have a 10% survival rate. By the 1960s about one third of patients were being cured with radiation. In 1970, the National Cancer Institute (NCI) reported that patients with advanced Hodgkin 's disease could attain complete remission and long-term survival using a combination chemotherapy of nitrogen mustard, Oncavin (vincristine), procarbazine, and prednisone, known as Mopp.
Lymphomas represent about 4% of new cancer cases diagnosed in the US each year. It is the fifth most common cancer diagnosis and the fifth leading cause of cancer death. Although the incidence of most cancers is decreasing, lymphoma is one of only two tumors increasing in frequency, although the cause for this increase in unknown. The American Cancer Society (ACS) estimated that 63,740 new cases of lymphoma will be diagnosed in the United States in 2005: of these 7350 will be Hodgkin;s disease and 56,390 will be
Chamberlain School of Nursing
Pathophysiology
J. Dobrzyn
May 31, 2013
Hodgkin 's Disease
In 1832 Thomas Hodgkin described a progressively fatal condition characterized by enormous lymph node swelling that he believed to be one disease. Characteristic cells involved in this disease were identified microscopically by Sternberg and Reed in 1898 and 1902, respectively. The identification of these cells, now known as Reed-Sternberg cells, allowed for the initial classification of Hodgkin 's disease. In the past two decades advances in histology and immunohistology have revealed that the Reed-Sternberg cell is B-cell lineage, and that Hodgkin 's disease is not a single cell, but instead two separate diseases. Hodgkin 's disease. The four stages of Hodgkin 's disease are based on factors such as location, whether cancer is found in more than one group of lymph nodes, or on one or both sides of the diaphragm. The potential curability of Hodgkin 's disease was first recognized in 1920, when patients with localized tumor with radiation were shown to have a 10% survival rate. By the 1960s about one third of patients were being cured with radiation. In 1970, the National Cancer Institute (NCI) reported that patients with advanced Hodgkin 's disease could attain complete remission and long-term survival using a combination chemotherapy of nitrogen mustard, Oncavin (vincristine), procarbazine, and prednisone, known as Mopp.
Lymphomas represent about 4% of new cancer cases diagnosed in the US each year. It is the fifth most common cancer diagnosis and the fifth leading cause of cancer death. Although the incidence of most cancers is decreasing, lymphoma is one of only two tumors increasing in frequency, although the cause for this increase in unknown. The American Cancer Society (ACS) estimated that 63,740 new cases of lymphoma will be diagnosed in the United States in 2005: of these 7350 will be Hodgkin;s disease and 56,390 will be
References: Mandle, C.(2010) Health Promotion Throughout the Life Span. Lois, Missouri: Mosby, Inc. Barker,D.& Osmond,, C. (2013) Hodgekin 's disease p1-1.1p Columbia Electromic Encyclopedia. 6th edition Meyers, J. Life Expectancy With Lymphoma. http://www.ehow.com/about_5513496_life-expectancy-lymphoma.html