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Practical and Clinical Applications
Fourth Edition, Revised and Expanded

Sanford Bolton
Visiting Professor University of Arizona Tucson, Arizona, U.S.A.

AAl Development Services
Wilmington, North Carolina, U.S.A.

Charles Bon

MARCEL

99.
DEKKER

MARCEL DEKKER, INC.

NEWYORK BASEL

Marcel Dekker, Inc. and the author(s) make no warranty with regard to the accompanying software, its accuracy, or its suitability for any purpose other than as described in the book. This software is licensed solely on an ‘‘as is’’ basis. The only warranty made is that the medium on which the software is recorded is free of defects. Marcel Dekker, Inc., will replace a diskette or CD-ROM found to be defective if such is not attributable to misuse by the purchaser or his agent. The defective diskette or CD-ROM must be returned within 10 days to: Customer Service, Marcel Dekker, Inc., Cimarron Road, Monticello, NY 12701. Although great care has been taken to provide accurate and current information, neither the author(s) not the publisher, not anyone else associated with this publication, shall be liable for any loss, damage, or liability directly caused or alleged to be caused by this book. The material contained herein is not intended to provide specific advice or recommendations for any specific situation. Trademark notice: Product or corporate names may be trademarks or registered trademarks and are used only for identification and explanation without intent to infringe. Library of Congress Cataloging-in-Publication Data A catalog record for this book is available from the Library of Congress. ISBN: 0-8247-4695-3 This book is printed on acid-free paper. Headquarters Marcel Dekker, Inc. 270 Madison Avenue, New York, NY 10016, U.S.A. tel: 212-696-9000; fax: 212-685-4540 Distribution and Customer Service Marcel Dekker, Inc. Cimarron Road, Monticello, New York 12701, U.S.A. tel: 800-228-1160; fax: 845-796-1772 Eastern Hemisphere Distribution Marcel Dekker AG, Hutgasse 4, Postfach 812, CH-4001 Basel, Switzerland tel: 41-61-260-6300; fax: 41-61-260-6333 World Wide Web http://www.dekker.com The publisher offers discounts onthis book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the headquarters address above. Copyright 2004 by Marcel Dekker, Inc. All Rights Reserve.

Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. Current printing (last digit): 10 9 8 7 6 5 4 3 2 1 PRINTED IN THE UNITED STATES OF AMERICA

DRUGS AND THE PHARMACEUTICAL SCIENCES
A Series of Textbooks and Monographs

1. Pharmacokinetics, Milo Gibaldi and Donald Peder 2. Good Manufacturing Practices for Pharmaceuticals: A Plan for Total Quality Control, Sidney H. Willig, Murray M. Tuckerman, and William S. Hitchings lV 3. Microencapsulation,edited by J. R. Nixon 4. Drug Metabolism: Chemical and Biochemical Aspects, Bernard Testa and Peter Jenner 5. New Drugs: Discovery and Development, edited by Alan A. Rubin 6. Sustained and Controlled Release Drug Delivery Systems, edited by Joseph R. Robinson 7. Modem Pharmaceutics, edited by Gilbert S. Banker and Christopher T. Rhodes 8. Prescription Drugs in Short Supply: Case Histories, Michael A. Schwartz 9. Activated Charcoal: Antidotal and Other Medical Uses, David 0. Cooney 10. Concepts in Drug Metabolism (in two parts), edited by Peter Jenner and Bernard Testa 11. Pharmaceutical Analysis: Modem Methods (in two parts), edited by James W. Munson 12. Techniques of Solubilization of Drugs, edited by Samuel H. Yalkowsky 13. Orphan Drugs, edited by Fred €. Karch 14. Novel Drug Delivery Systems: Fundamentals, Developmental Concepts, Biomedical Assessments, Yie W. Chien 15. Pharmacokinetics: Second Edition, Revised and Expanded, Milo Gibaldi...
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