Grignard Reaction

Topics: Magnesium, Diethyl ether, Grignard reaction Pages: 4 (1185 words) Published: March 21, 2011
Nucleophilic Addition to a Carbonyl: The Grignard Reaction

Mechanism:

Formation of phenylmagnesium bromide:

Phenylmagnesium bromide and methyl benzoate reaction:

Procedure: Procedure in lab manual should be sufficient.
Data Table:

The Grignard Reaction
|Reagents |MW (g/mol) |Amount used |Lit. Melting Point |Mol used |Mol equivalent | | | | |((c) | | | |Bromobenzene |157.02 g/mol |3.20 g |-30.8°C |.0204 mol |1 | |Methyl Benzoate |136.15 g/mol |1.27 mL |-12.8°C |.0100 mol |1 | |Magnesium |24.10 g/mol |.604g |650°C |.0255 mol |1.25 |

|Products |MW (g/mol) |Amount Obtained (g) |% Yield |Lit. Melting Point |Observed Melting Point| | | | | |(°C) |(°C) | |Crude |260.34 g/mol |1.00g |37.6 % |160-163°C |159-161.C | |Recrystallized |260.34 g/mol |.238g |28.8% (% recovered) |160-163°C |160-162°C | |Crude | | | | | |

|Compound |Crude Melting Point (°C) |Recrystallization Melting |% Yield |% Recovery | | | |Point (°C) | | | |Aldehyde |55.2-58°C...
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