Furosemide

NAME | MECHANISM OF ACTION | INDICATION | CONTRAINDICATION | ADVERSE REACTION | NURSING RESPONSIBILITIES | GENERIC NAME:furosemideBRAND NAME:LasixDRUG CLASSIFICATION:Loop DiureticDOSAGE:Adults-Edema: initially, 20-80mg/day PO as single dose. If needed, a second dose may be given in 6-8 hour.-acute pulmonary edema 40mg IV over 1-2 minute maybe increased to 80mg IV given over 1-2 min if response is unsatisfactory after 1 hour. -hypertension: 40mg BID PO, if needed, additional hypertensive may be added.PEDIATRICS-Edema: 2mg/kg/day PO-pulmonary edema:1mg/kg/IV or IM. May increase by 1mg/kg in 2hour.ROUTE: Oral, IV, IM | Inhibits reabsorption of sodium and chloride from the proximal and distal tubules and ascending limb of the loop of Henle, leading to a sodium rich dieresis. | ORAL,IV: Edema, associated with heart failure, cirrhosis, renal diseaseIV: acute pulmonary edemaORAL: hypertension | Contraindicated with allergy to furosemide, sulfonamides, allergy to tartrazine (in oral solution); anuria, severe renal failure, hepatic coma, pregnancy, lactation.Use cautiously with SLE- Systemic Lupus Erythmatous, gout, diabetes mellitus | CNS: dizziness, vertigo, paresthesias, weakness, headache, drowsiness, fatigue, blurred vision. Hearing lossCV: orthostatic hypotension, thrombophlebitisDermatologic: photosensitivity, rash, urticariaGI: nausea, anorexia, vomiting, oral and gastric irritation, constipation.GU: urinary bladder spasm, polyuria, glycosuriaHematologic: Leukopenia, anemia, thrombocytopeniaOther: muscle cramps, muscle spasms | 1. Administer with food or milk to prevent GI upset. 2. Reduce dosage if given with other hypertensive drug, readjust dosage gradually as BP responds. 3. Give early in the day so that increased urination will not disturb sleep. 4. Do not expose to light, which may discolor tablets or solutions. 5. Discard diluted solutions after 24h. 6. Refrigerate oral solutions. 7. Measure and record weight to monitor fluid