Frederick Griffith

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Frederick Griffith
Biography
Frederick Griffith (1879-1941), who was born in Hale, Cheshire County, England and who attended the Liverpool University, was a British bacteriologist whose focus was the epidemiology and pathology of bacterial Pneumonia. In January, 1928 he reported what is now known as Griffiths Experiment, the first widely accepted demonstration of bacterial transformation, where a bacterium distinctly changes its form and function. Griffith succumbed to his death around the year 1941 due to the air raid.

His Purpose and what he derived?
Griffith showed that Streptococcus pneumonia, could transform from one strain into a different strain. The observation was attributed to an unidentified transforming principle of transforming Factor. This was later identified as the stuff of life “DNA”

The Experiment
Griffith’s experiment, reported in 1928, was one of the first experiments suggesting that bacteria are capable of transferring genetic information through a process known as transformation. Griffith went about deriving his results by means of using two strains of Pneumoccocus (Streptococcus pneumonia) bacteria which he used to infect several mice. A type smooth strain and a type rough strain. The smooth strain has its components covered by a polysaccharide capsule, which gives it the ability to live in adverse conditions and divide rapidly through a process called Binary fission. Adverse conditions in the context of this experiment would mean “protection from white blood cells” The third line of defense’s inability to phagocytize the bacteria subsequently results in the death of the mice because the capsule accommodates for the rapid growth of the same cell. Bacterial cells usually have a target organ to which it chooses to disintegrate, and in the case of abundance, the more the number of bacterial cells the more likely the host is going to succumb to it death.

How the Experiment was Set up?
The experiment was set up by means of...
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