| Student Response
Part IOriginal DNA Strand: 3’-TACCCTTTAGTAGCCACT-5’
| Transcription (base sequence of RNA): 5’…AUGGGAAAUCAUCGGUGA…3’
| Translation (amino acid sequence): AUG(the start code/ methoninie), GGA (Glycine), AAU (Asparagine), CAU (Histidine), CGG (Arginine), UGA (Stop code)
What is the significance of the first and last codons?
| Explanation: The significance of the first and last codons is that theay are the start code and the stop code.
| What meaning do these codons have for protein synthesis?
| Explanation: The meaning they have for protein synthesis is that the start code tells where to start synthesis and the stop code tells where to stop synthesis.
| Mutation TranscriptionsOriginal sequence: 3’- TACCCTTTAGTAGCCACT-5’
| Transcribe the Mutations of RNA: 3’-TACGCTTTAGTAGCCATT-5'
| Transcriptions of Mutations: AUGCGAAAUCAUCGGUAA
AUU GGA AAU GAU CCG UGA
| Translations of Mutations (amino acid sequences for each): AUG (start code/ methonine), CGA (Arginine), AAU (Asparagine), CAU (Histidine), CGG (Arginine), UAA (Stop code)
| AUU (Lisoleucine), GGA (Glycine), AAU (Asparagine), GAU (Aspartic acid), CCG (Proline), UGA (Stop code)
Does the protein sequence change for either of these examples? If so, how?
| Explain in general why a change in amino acid sequence might affect protein function.
| Explanation: The Change in Amino Acid sequence might affect the protein function because for example in mutated sequence number 2 there is no start code meaning this would never get translated.
| GRAPHIC ORGANIZER
Part IIPunnett Square a. Chances (25%) for healthy child, not a carrier b. Chances (50%) for child that is carrier for cystic fibrosis trait c. Chances (25%) for child with cystic fibrosis1:2:1 - genotypic 3:1- phenotypic
| Fill out/adapt Punnett Square: CC
a. Chances (25%) for healthy...
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