Fanconi's Anemia and Sickle Cell Anemia

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Fanconi's Anemia and Sickle Cell Anemia

By | December 2011
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Fanconi’s anemia and sickle cell anemia
 
Sickle cell anemia
Sickle cell anemia is classified as an autosomal recessive genetic disorder. This implies that for this disease to take place within any individual, it is necessary that the person needs to be a homozygous recessive for it. The disease takes place among children at the time of their birth allowing their red blood cells to become sickle shaped which has a direct affect upon the transport of oxygen and hemoglobin on their bodies. It is also important to mention here that the incidence of sickle cell anemia is highly prevalent in countries where malaria is an epidemic. This is so because malaria itself increases the susceptibility of an individual towards sickle cell anemia. However, along with this there is also an interesting dimension that needs to be highlighted when we are discussing the different dynamics and dimensions of this disorder. As mentioned earlier the disease is found in people who possess recessive alleles coming from both parents. Hence, people who are homozygous dominant do not suffer from sickle cell anemia, but are vulnerable towards suffering from malaria as their red blood cells can get easily infected by its causative agent. (Brown, 2006) People who are homozygous recessive suffer from sickle cell anemia and hence encounter the problem of ensuring proper transport of oxygen in their red blood cells. It is basically the intermediate or the heterozygous population which are at a selective advantage from malaria as well as sickle cell anemia. This process is usually referred to as co-dominance when each allele exerts its effect and expresses itself as an individual and specific entity. Hence the dominant allele prevents the incidence of sickle cell whereas the recessive allele prevents the incidence of sickle cell anemia. This phenomenon is commonly referred to as heterozygotic superiority. Nevertheless in case of occurrence sickle cell anemia results in various forms of acute and...
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