Extraction and Evaporation. Separating the Components of “Panacetin”

Solubility, Liquid–liquid extraction

Subject:Experiment # 2: Extraction and Evaporation. Separating the Components of “Panacetin”

The problem proposed in the experiment is an unknown ingredient found in generic Panacetin tablets that must be discovered. Panacetin tablets are known to contain aspirin, acetaminophen, and sucrose; therefore, the tablets tested, containing aspirin and sucrose, are thought to contain an unknown of something similar to that of acetaminophen such as acetanilide or phenacetin. Another problem trying to be sought out in the experiments is whether or not the composition of Panacetin as stated on the label is accurate.

The experiment involved the separation of the unknown from the Panacetin by first isolating the sucrose and the aspirin. This process was done by starting with three grams of Panacetin and adding dichloromethane to dissolve and then separating the sucrose by filter-gravity filtration. The aspirin was then separated with the help of sodium hydroxide to isolate the unknown. From the values found, we were able to find percentages of sucrose, aspirin, and the unknown in relation to what is found on the labels of these tablets.

In the process of separating the sucrose, aspirin, and unknown several observations were made. When the dichloromethane was added to the Panacetin the Panacetin dissolved in the chemical. With the use of filter-gravity filtration the sucrose separated into a dry white substance. The filtrate left over was added with sodium hydroxide in a separatory funnel in which the sodium hydroxide and filtrated dichloromethane separated into two distinct layers before being transferred into two separate containers. Hydrochloric acid then had to be added to the aqueous layer of sodium hydroxide and aspirin, and then separated by vacuum filtration to form another dried substance. The unknown from the solution of dichloromethane and the unknown were isolated by aspiration, in which the unknown turned into a more...
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