European Consumer Exposure to Cosmetic Products

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  • Topic: Mean, Cosmetics, Population modeling
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Food and Chemical Toxicology 45 (2007) 2097–2108 www.elsevier.com/locate/foodchemtox

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European consumer exposure to cosmetic products, a framework for conducting population exposure assessments B. Hall a,*, S. Tozer b, B. Safford c, M. Coroama d, W. Steiling e, M.C. Leneveu-Duchemin f, C. McNamara g, M. Gibney h b a ` ´ L’Oreal, Worldwide Safety Evaluation, River Plaza 25-29 quai Aulagnier, 92600 Asnieres-sur-Seine, France Procter & Gamble, Central Product Safety, P&G Technical Centres Ltd., Whitehall Lane, Egham, Surrey TW20 9NW, UK c Unilever, Safety and Environmental Assurance Centre, Colworth Park, Sharnbrook, Beds MK44 1LQ, UK d Colipa, Avenue Hermann-Debroux 15A, B-1160 Brussels, Belgium e Henkel KGaA, Corporate SHE and Product Safety-Human Safety Assessment, Henkelstr. 67, 40191 Dusseldorf, Germany f Beiersdorf AG, Unnastrasse 48, 20245 Hamburg, Germany g CREMe Software Ltd., Innovation Centre, Trinity College, Dublin 2, Ireland h Agriculture and Food Centre, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland

Received 31 January 2007; accepted 1 June 2007

Abstract Access to reliable exposure data is essential to evaluate the toxicological safety of ingredients in cosmetic products. This study was carried out by European cosmetic manufacturers acting within the trade association Colipa, with the aim to construct a probabilistic European population model of exposure. The study updates, in distribution form, the current exposure data on daily quantities of six cosmetic products. Data were collected using a combination of market information databases and a controlled product use study. In total 44,100 households and 18,057 individual consumers in five European countries provided data using their own products. All product use occasions were recorded, including those outside of home. The raw data were analysed using Monte Carlo simulation and a European Statistical Population Model of exposure was constructed. A significant finding was an inverse correlation between frequency of product use and quantity used per application for body lotion, facial moisturiser, toothpaste and shampoo. Thus it is not appropriate to calculate daily exposure to these products by multiplying the maximum frequency value by the maximum quantity per event value. The results largely confirm the exposure parameters currently used by the cosmetic industry. Design of this study could serve as a model for future assessments of population exposure to chemicals in products other than cosmetics. Ó 2007 Elsevier Ltd. All rights reserved. Keywords: Cosmetics; Exposure; Probabilistic analysis; Monte Carlo; Statistical population modelling

Contents 1. 2. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . Materials and methods . . . . . . . . . . . . . . . . . . . 2.1. Test products. . . . . . . . . . . . . . . . . . . . . . 2.2. Countries of investigation . . . . . . . . . . . . 2.3. Data sources – study input. . . . . . . . . . . . . . . . . ......................... ......................... .......................... .......................... .......................... ......................... ......................... .......................... .......................... .......................... . . . . . 2098 2099 2099 2099 2099

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Corresponding author. Tel.: +33 1 47 56 79 27; fax: +33 1 47 56 72 68. E-mail address: bhall@rd.loreal.com (B. Hall).

0278-6915/$ - see front matter Ó 2007 Elsevier Ltd. All rights reserved. doi:10.1016/j.fct.2007.06.017

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B. Hall et al. / Food and Chemical Toxicology 45 (2007) 2097–2108

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2.3.1. European toiletries and cosmetics database (ETCD) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.3.2. ISC database . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.3.3. TNS-Europanel database. . . . . . . . . . ....
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