Emphysema(COPD) may be caused by a genetic deficiency of alpha 1 -antitrypsin (AAN) and by cigarette smoking. Genetically, one in 3,000 newborns are found with the disease, and 1% to 3% of all cases of emphysema are due to AAT deficiency. Cigarette smoking is thought to cause 20% of the cases. Other causative factors are unknown. Complications
In emphysema(COPD), complications may include recurrent respiratory tract infections, cor pulmonale, and respiratory failure. Peptic ulcer disease strikes 20% to 25% of patients with COPD. Additionally, alveolar blebs and bullae may rupture, leading to spontaneous pneumothorax or pneumomediastinum. Assessment findings
The patient history may reveal that the patient is a long-time smoker. The patient may report shortness of breath and a chronic cough. The history may also reveal anorexia with resultant weight loss and a general feeling of malaise.
Inspection may show a barrel-chested patient who breathes through pursed lips and also uses accessory muscles. You may notice peripheral cyanosis, clubbed fingers and toes, and tachypnea.
Palpation may reveal decreased tactile fremitus and decreased chest expansion. Percussion may detect hyper resonance. On auscultation, you may hear decreased breath sounds, crackles and wheezing during inspiration, a prolonged expiratory phase with grunting respirations, and distant heart sounds. Diagnostic tests
Chest X-rays in advanced disease may show a flattened diaphragm, reduced vascular markings at the lung periphery, over aeration of the lungs, a...