One Sunday, they pass a certain house with a door unlike those in the rest of the neighborhood. The door reminds Mr. Enfield of a previous incident in which he witnessed an extremely unpleasant man trampling upon a small, screaming girl while the strange man was in flight from something, or to somewhere. The screams from the small girl brought a large crowd, and various bystanders became incensed with the indifference of the stranger, whose name they discovered to be Mr. Edward Hyde. Enfield can recall the man only with extreme distaste and utter revulsion. The crowd forced the man to make retribution in the form of money, and they were all surprised when he returned from inside the "strange door" with ten pounds in gold and a check for ninety pounds. They held him until the banks opened to make certain that the check was valid because it was signed by the well-known Dr. Henry Jekyll, and they suspected that it was a forgery. To their amazement, the check was valid.
That evening, in his apartment, Mr. Utterson has further reason to be interested in Mr. Hyde because Dr. Jekyll's will has an unusual clause that stipulates that Edward Hyde is to be the sole beneficiary of all of Jekyll's wealth and property. Utterson goes, therefore, to visit an old friend, Dr. Lanyon, who tells him that some ten years ago, he and Dr. Jekyll became estranged because of a professional matter. Utterson decides to seek out Hyde, and he posts himself as a sentinel outside the mysterious door previously mentioned by Enfield. After some time, Utterson encounters the man Hyde entering the door, and he initiates a conversation with him. Hyde suddenly becomes highly suspicious of Utterson's interest in him and quickly retreats inside the door. Utterson walks around the block and knocks at the front door of Dr. Jekyll's house. Upon questioning the butler, Poole, Utterson discovers that Edward Hyde has complete access to Jekyll's house.
About a fortnight later, Utterson is invited to one of Jekyll's dinner parties and remains after the other guests have left so that he can question Jekyll about his will and about his beneficiary, Edward Hyde. Jekyll is unhappy discussing Edward Hyde and insists that his wishes — that Mr. Hyde be the recipient of his property — be honored.
About a year later, an upstairs maid witnesses the vicious murder of a kindly and distinguished old gentleman, the prominent Sir Danvers Carew, M.P. (Member of Parliament). But the assailant escapes before he can be apprehended. The maid, however, is able to positively identify the murderer as Edward Hyde. Mr. Utterson and the police go to Hyde's apartment, but the housekeeper informs them that he is gone. When Utterson confronts Jekyll about the whereabouts of Hyde, Jekyll shows the lawyer a letter which Hyde wrote saying that he was disappearing forever. Jekyll maintains that he himself is completely through with him.
After the disappearance of Hyde, Jekyll comes out of his seclusion and begins a new life, for a time. But at about the same time, Utterson is dining with his friend, Dr. Lanyon, and he notes that Dr. Lanyon seems to be on the verge of a complete physical collapse; Lanyon dies three weeks later. Among his papers is an envelope addressed to Utterson, and inside is an inner envelope, sealed with instructions that this envelope should not be opened until after Jekyll's death or disappearance. Utterson strongly feels that the contents of the envelope contain information about Edward Hyde.
On another Sunday walk, Utterson and Enfield pass along the street where Enfield saw Hyde trampling on the young girl. They step around the corner into the courtyard and see Dr....