Juvenile Diabetes (Type 1 Diabetes) March 17, 2013
Diabetes was first discovered as far back as 6th century BC by an Indian physician Sushruta. He recognized that people showing certain symptoms all had sweet urine. He called this condition Madhumeha. In 1869 a young medical student in Berlin named Paul Langerhans was interested in learning about the structure of the pancreas. He discovered there were clumps of tissue clustered in the pancreas. Langerhans never learned the function of this tissue. These cells became known as the Islets of Langerhans. He never realized he would be associated with who discovered diabetes. Langerhans' son, Archibald, and another man, Edouard Laguesse, later thought these clusters of cells might secrete something that helped regulate digestion .In 1889 Oscar Minkowski, a Polish-German physician, along with Joseph von Mering wanted to understand more about the role of the pancreas in digestion. They removed the pancreas from a dog to study it. Several days later, a lab technician noticed that flies swarmed the area where the dog had urinated. Minkowski and von Mering tested the urine and found sugar. This was the first link between the pancreas and diabetes. In 1901 Eugene Opie confirmed that the Islets of Langerhans and diabetes were connected. He is quoted to say, “Diabetes mellitus...is caused by destruction of the islets of Langerhans and occurs only when these bodies are in part or wholly destroyed.” So now the medical community knew that the pancreas, particularly the islets of Langerhans, was not functioning in a person with diabetes. For the next 20 years, the discovery of insulin evaded those who researched the pancreas. 1906 George Ludwig Zuelzer was able to extract some secretions from the pancreas. He had some success treating dogs. But he couldn't get support to continue his work. Juvenile diabetes (type 1 diabetes) is usually diagnosed in children and adolescent. It occurs when the pancreas is unable to produce...
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