Development of Sorbitan Monostearate Organogels for Controlled Delivery Systems

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DEVELOPMENT OF SORBITAN MONOSTEARATE ORGANOGELS
FOR CONTROLLED DELIVERY SYSTEMS

A THESIS SUBMITTED IN PARTIAL FULFILLMENT
OF THE REQUIREMENTS FOR THE DEGREE OF

Bachelor of Technology (Biomedical Engineering)

Submitted
By

MEENAKSHI SINGH
Roll No. 107BM008

Under the Guidance of
Dr. Kunal Pal

Department of Biotechnology & Medical Engineering
National Institute of Technology
Rourkela 769008

DEPARTMENT OF BIOTECHNOLOGY & MEDICAL ENGINEERING,
NATIONAL INSTITUTE OF TECHNOLOGY-ROURKELA

Dated: May 14, 2011

CERTIFICATE

This

is

to

certify

that

the

thesis

entitled

“DEVELOPMENT

OF

SORBITAN

MONOSTEARATE ORGANOGELS FOR CONTROLLED DELIVERY SYSTEMS”
submitted by Ms. MEENAKSHI SINGH in partial fulfilment for the requirements for the award of Bachelor of Technology Degree in Biotechnology at National Institute of Technology, Rourkela is an authentic work carried out by him under the supervision of the undersigned. To the best of my knowledge, the matter embodied in the thesis has not been submitted to any other University / Institute for the award of any Degree or Diploma.

(Dr. KUNAL PAL)
Assistant Professor

2

ACKNOWLEDGEMENT

I would like to express my deep sense of gratitude and respect to our supervisor, Dr. Kunal Pal, for his excellent guidance, suggestions and constructive criticism. I extend my gratitude to all staff members of Department of Biotechnology and Medical Engineering, NIT, Rourkela, for extending their help, as and when required. I would like to thank my parents and friends, without whose unconditional love and support, this work would not have been possible. Last but not the least, I would like to extend my heartfelt gratitude to the M.Tech and Ph.D students of Department of Biotechnology and Medical Engineering, NIT, Rourkela whose ever helping nature and suggestions has helped me to complete this present work.

.
Meenakshi Singh.
Roll no.: 107BM008.

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ABSTRACT

The study describes the development of sorbitan monostearate (Span 60) based organogels with mustard oil as the solvent. Different compositions of organogels were prepared by varying the concentrations of span 60. During the preparation of organogels, their microstructures were studied under compound light microscope. The formulated organogels were characterized by light microscopy,

gel-to-sol transition temperature, long-term stability, pH, opacity

measurements and hemocompatibilty studies. Metronidazole was incorporated within the organogels and its release behaviour was determined. The anti-microbial action of the drugloaded organogels on E. coli was studied. The microscopy of the organogels suggests that a three-dimensional network of rod-like tubular aggregates of gelator is responsible for immobilising the solvent. Clusters of span 60 are visualised as dispersed in the liquid phase. The rate of formation of organogels and the release rate of metronidazole from the organogels was found to depend on span 60 proportions in the formulated organogels. The pH of the samples was found to be in the range of 6.4-7.1. The organogels were found to be hemocompatible in nature indicating their probable use as controlled delivery vehicles.

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Table of Contents
1.

INTRODUCTION .................................................................................................................................... 8

2.

REVIEW OF LITERATURE ..................................................................................................................... 10 2.1
2.2

3.

OVERVIEW OF DRUG DELIVERY .................................................................................................. 10 GELS ............................................................................................................................................ 11

MATERIALS AND METHODS...
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